肿瘤细胞与微环境之间相互作用,对于肿瘤的发生发展、免疫反应以及耐药性产生重要影响。本实验室前期工作揭示脑瘤和乳腺癌等肿瘤细胞中调控免疫反应的表观遗传通路(Cell 2021;Cancer Discovery 2021),并建立大规模病人来源肝癌细胞系平台描绘肝癌的药物基因组学图谱(Cancer Cell 2019,“2019年度中国生物信息学十大应用”)。在此基础上,本实验室利用单细胞测序和CRISPR/Cas9筛选等,利用中国患者来源的肿瘤细胞培养、小鼠模型和患者样本,研究脑肿瘤细胞的表观遗传调控及与肿瘤微环境的相互作用,以及脑肿瘤细胞的耐药机制,发现新的治疗靶点和联合用药方式。
Zhixin Qiu#, Linjie Zhao#, Jia Z Shen#, Zhengyu Liang, Qiulian Wu, Kailin Yang, Lihua Min, Ryan Gimple, Qiyuan Yang, Shruti Bhargava, Chunyu Jin, Cheryl Kim, Denise Hinz, Deobrat Dixit, Jean Bernatchez, Briana Prager, Guoxin Zhang, Zhen Dong, Deguan Lv, Xujun Wang, Leo Kim, Zhe Zhu, Katherine jones, Ye Zheng, Xiuxing Wang, Jair Siqueira-Neto, Lukas Chavez, Xiangdong Fu, Charles Spruck, and Jeremy Rich. Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells. Cancer Discovery 2021 online.
Jia Z Shen#, Zhixin Qiu#, Qiulian Wu, Darren Finlay, Guillermina Garcia, Dahui Sun, Juha Rantala, William Barshop, Jennifer L Hope, Ryan C Gimple, Olle Sangfelt, Linda M Bradley, James Wohlschlegel, Jeremy N Rich*, Charles Spruck*. FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells. Cell 2021; 184(2):352-369.e23.
Zhixin Qiu#, Hong Li#, Zhengtao Zhang#, Zhenfeng Zhu, Sheng He, Xujun Wang, Pengcheng Wang, Jianjie Qin, Liping Zhuang, Wei Wang, Fubo Xie, Ying Gu, Keke Zou, Chao Li, Chun Li, Chenhua Wang, Jin Cen, Xiaotao Chen, Yajing Shu, Zhao Zhang, Lulu Sun, Lihua Min, Yong Fu, Xiaowu Huang, Hui Lv, He Zhou, Yuan Ji, Zhigang Zhang, Zhiqiang Meng, Xiaolei Shi*, Haibin Zhang*, Yixue Li*, Lijian Hui*. A Pharmacogenomic Landscape in Human Liver Cancers. Cancer Cell 2019; 36(2):179-193.e11.
Zhixin Qiu#, Keke Zou#, Liping Zhuang#, Jianjie Qin#, Hong Li, Chao Li, Zhengtao Zhang, Xiaotao Chen, Jin Cen, Zhiqiang Meng*, Haibin Zhang*, Yixue Li*, Lijian Hui*. Hepatocellular carcinoma cell lines retain the genomic and transcriptomic landscapes of primary human cancers. Scientific Reports 2016; 27411.