Xiaoxue Jiang #, Kan liu#, Peixiang Luo, Zi Li, Fei Xiao, Haizhou Jiang, Shangming Wu, Min Tang, Feixiang Yuan, Xiaoying Li, Yousheng Shu, Bo Peng Shanghai Chen, Shihong Ni and Feifan Guo*. Hypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue of male mice. Nat Commun. 2024 Sep 11;15(1):7948.

Yuguo Niu #, Xiaoming Hu #, Yali Song #, Cunchuan Wang, Peixiang Luo, Shihong Ni, Fuxin Jiao, Ju Qiu, Weihong Jiang, Sheng Yang, Jun Chen, Rui Huang, Haizhou Jiang, Shanghai Chen, Qiwei Zhai, Jia Xiao*, and Feifan Guo*. Blautia coccoides is a newly identified bacterium increased by leucine deprivation and has a novel function in improving metabolic disorders. Adv Sci. 2024 May;11(18):e2309255.

Yuan Feixiang^#, Zhou Ziheng^#, Wu Shangming, Jiao Fuxin, Chen Liang, Fang Leilei, Yin Hanrui, Hu Xiaoming, Jiang Xiaoxue, Liu Kan, Xiao Fei, Jiang Haizhou, Chen Shanghai, Liu Zhanju, Shu Yousheng and Guo Feifan*. Intestinal activating transcription factor 4 regulates stress-related behavioral alterations via paraventricular thalamus in male mice. PNAS. 2023 May 9;120(19):e2215590120.

Xiao Fei^#, Jiang Haizhou^#, Li Zi, Jiang Xiaoxue, Chen Shanghai, Niu Yuguo, Yin Hanrui, Shu Yousheng, Peng Bo, Lu Wei, Li Xiaoying, Li Zhigang, Lan Shujue, Xu Xiaoyan, Guo Feifan *. Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice. Nature Communications. 2023 May 2;14(1):2523.

Hu Xiaoming^#, Jiao Fuxin^#, Deng Jiali, Zhou Ziheng, Chen Shanghai, Liu Changqin, Liu Zhanju*, Guo Feifan*. Intestinal epithelial cell-specific deletion of cytokine-inducible SH2- containing protein alleviates experimental colitis in ageing mice. J Crohns Colitis. 2023 Mar 7;jjad041

Jiao Fuxin, Hu Xiaoming, Yin Hanrui, Yuan Feixiang, Zhou Ziheng, Wu Wei, Chen Shanghai, Liu Zhanju, Guo Feifan*. Inhibition of c-Jun in AgRP neurons increases stress-induced anxiety and colitis susceptibility. Commun Biol. 2023 Jan 14;6(1):50.

Yuan Feixiang, Wu Shangming, Zhou Ziheng, Jiao Fuxin, Yin Hanrui, Niu Yuguo, Jiang Haizhou, Chen Shanghai, Guo Feifan*. Leucine deprivation results in antidepressant effects via GCN2 in AgRP neurons. Life Metabolism. 2023 Advance access publication 4 February. doi.org/10.1093/lifemeta/load004

Jiang Xiaoxue, liu Kan, Jiang Haizhou, Yin Hanrui, Wang En-duo, Cheng Hong, Yuan Feixiang, Xiao Fei, Wang Fenfen, Lu Wei, Peng Bo, Shu Yousheng, Li Xiaoying, Chen Shanghai, Guo Feifan*. SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2. Cell Reports. 2023 Jan 31;42(1):111984.

Jiang Xiaoxue, Xiao Fei and Guo Feifan*. Oocyte TET3: an epigenetic modifier responsible for maternal inheritance of glucose intolerance. Signal Transduction and Targeted Therapy. 2022 Oct 8;7(1):357. 

Hu Xiaoming^#, Niu Yuguo^#, Luo Pepxiang, Xiao Fei, Yuan Feixiang, Yin Hanrui, Chen Shanghai, Guo Feifan*. Amino acid sensor GCN2 promotes SARS-CoV-2 receptor ACE2 expression in response to amino acid deprivation. Communications Biology. 2022 Jul 1;5(1):651.

Xiao Fei^#, Deng Jiali^#, Jiao Fuxin, Hu Xiaoming, Jiang Haizhou, Yuan Feixiang, Chen Shanghai, Niu Yuguo, Jiang Xiaoxue, Guo Feifan*. Hepatic cytokine-inducible SH2-containing protein (CISH) regulates gluconeogenesis via cAMP-responsive element binding protein (CREB). FASEB J. 2022 Oct;36(10):e22541.

Niu Yuguo, Jiang Haizhou, Yin Hanrui, Wang Fenfen, Hu Ronggui, Hu Xiaoming, Peng Bo, Shu Yousheng, Li Zhigang, Chen Shanghai, Guo Feifan*. Hepatokine ERAP1 Disturbs Skeletal Muscle Insulin Sensitivity Via Inhibiting USP33-Mediated ADRB2 Deubiquitination. Diabetes. 2022 May 1;71(5):921-933. 

Yin Hanrui, Yuan Feixiang, Jiao Fuxin, Niu Yuguo, Jiang Xiaoxue, Deng Jiali, Guo Yajie, Chen Shanghai, Zhai Qiwei, Hu Cheng*, Li Yiming*, Guo Feifan*. Intermittent Leucine Deprivation Produces Long-lasting Improvement in Insulin Sensitivity by Increasing Hepatic Gcn2 Expression. Diabetes. 2022 Feb 1;71(2):206-218

Hu Xiaoming, Guo Feifan*. Amino Acid Sensing in Metabolic Homeostasis and Health. Endocr Rev. 2021 Feb;42(1):56-76.(Invited review); Selected as "Featured article" by Endocrine Reviews

Yuan Feixiang, Jiang Haizhou, Yin Hanrui, Jiang Xiaoxue, Jiao Fuxin, Chen Shanghai, Ying Hao, Chen Yan, Zhai Qiwei, Guo Feifan*. Activation of GCN2/ATF4 Signals in Amygdalar PKC-δ Neurons Promotes WAT Browning Under Leucine Deprivation. Nat Commun. 2020 Jun 5;11(1):2847

Deng Jiali, Guo Yajie, Yuan Feixiang, Chen Shanghai, Yin Hanrui, Jiang Xiaoxue, Jiao Fuxin, Wang Fenfen, Ji Hongbin, Hu Guohong, Ying Hao, Chen Yan, Zhai Qiwei, Xiao Fei*, Guo Feifan*. Autophagy inhibition prevents glucocorticoid-increased adiposity via suppressing BAT whitening. Autophagy. 2020 Mar;16(3):451-465

Hu Xiaoming, Deng Jiali, Yu Tianming, Chen Shanghai, Ge Yadong, Zhou Ziheng, Guo Yajie, Ying Hao, Zhai Qiwei, Chen Yan, Yuan Feixiang, Niu Yuguo, Shu Weigang, Chen Huimin, Ma Caiyun, Liu Zhanju*, Guo Feifan*. ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides. Gastroenterology. 2019 Mar;156(4):1098-1111

Deng Yalan, Xiao Yuzhong, Yuan Feixiang, Liu Yaping, Jiang Xiaoxue, Deng Jiali, Fejes-Toth Geza, Naray-Fejes-Toth Aniko, Chen Shanghai, Chen Yan, Ying Hao, Zhai Qiwei, Shu Yousheng*, and Guo Feifan*. SGK1/FOXO3 Signaling in Hypothalamic POMC Neurons Mediates Glucocorticoid-Increased Adiposity. Diabetes. 2018 Apr;67(4):569-580

Xiao Yuzhong, Deng Yalan, Yuan Feixiang, Xia Tingting, Liu Hao, Li Zhigang, Chen Shanghai, Liu Zhixue, Ying Hao, Liu Yong, Zhai Qiwei, Guo Feifan*. An ATF4-ATG5 signaling in hypothalamic POMC neurons regulates obesity. Autophagy. 2017 Jun 3;13(6):1088-1089

Xiao Yuzhong, Deng Yalan, Yuan Feixiang, Xia Tingting, Liu Hao, Li Zhigang, Liu Zhixue, Ying Hao, Liu Yi, Zhai Qiwei, Chen Shanghai, Guo Feifan*. An ATF4/ATG5 signaling in hypothalamic POMC neurons regulates fat mass via affecting energy expenditure. Diabetes. 2017 May;66(5):1146-1158

Deng Jiali^#, Yuan Feixiang^#, Guo Yajie, Xiao Yuzhou, Niu Yuguo, Deng Yalan, Han Xiao, Guan Youfei, Chen Shanghai, and Guo Feifan*.Deletion of ATF4 in AgRP neurons promotes fat loss mainly via increasing energy expenditure.Diabetes.2017 Mar,66(3):640-650

Guo Yajie^#, Yu Junjie^#, Deng Jiali, Liu Bin, Xiao Yuzhong, Li Kai, Xiao Fei, Yuan Feixiang, Liu Yong, Chen Shanghai, and Guo Feifan*. A Novel Function of Hepatic FOG2 in Insulin Sensitivity and Lipid Metabolism Through Peroxisome Proliferator–Activated Receptor alpha. Diabetes. 2016 Aug;65(8):2151-63

Xiao Fei^#, Deng Jiali^#, Guo Yajie, Niu Yuguo, Yuan Feixiang, Yu Junjie, Chen Shanghai, Guo Feifan*. BTG1 ameliorates liver steatosis by decreasing stearoyl-CoA desaturase 1 (SCD1) abundance and altering hepatic lipid metabolism. Science Signaling. 2016 May 17;9(428):ra50

Xiao Yuzhong^#, Liu Hao^#,Yu Junjie, Zhao Zilong, Xiao Fei, Xia Tingting, Wang Chunxia, Li Kai, Deng Jiali, Guo Yajie, Chen Shanghai, Chen Yan and Guo Feifan*. MAPK1/3 regulate hepatic lipid metabolism via ATG7-dependent autophagy. Autophagy.2016;12(3):592-3

Xiao Yuzhong^#, Liu Hao^#,Yu Junjie, Zhao Zilong, Xiao Fei, Xia Tingting, Wang Chunxia, Li Kai, Deng Jiali, Guo Yajie, Chen Shanghai, Chen Yan and Guo Feifan*. Activation of ERK1/2 ameliorates liver steatosis in leptin receptor deficient (db/db)mice via stimulating ATG7-dependent autophagy. Diabetes. 2016 Feb;65(2):393-405

Yu Junjie, Xiao Fei, Guo Yajie, Deng Jiali, Liu Bin, Zhang Qian, Li Kai, Wang Chunxia, Chen Shanghai, and Guo Feifan*. Hepatic phosphoserine aminotransferase 1 (PSAT1) regulates insulin sensitivity in mice via tribbles homolog 3 (TRB). Diabetes. 2015 May;64(5):1591-602

Xiao Fei, Yu Junjie, Liu Bin, Guo Yajie, Li Kai, Deng Jiali, Zhang Junzhi, Wang Chunxia, Chen Shanghai, Du Ying, Lu Yingli, Xiao Yuzhong, Zhang Zhou, and Guo Feifan*. A Novel Function of MicroRNA 130a-3p in Hepatic Insulin Sensitivity and Liver Steatosis. Diabetes. 2014, 63: 2631-2642

Yu Junjie#, Xiao Fei#, Zhang Qian, Liu Bin, Guo Yajie, Lv Ziquan, Xia Tingting, Chen Shanghai, Li Kai, Du Ying, and Guo Feifan*. Prolactin Receptor (PRLR) regulates hepatic insulin sensitivity in mice via Signal Transducer and Activator of Transcription (STAT)5. Diabetes. 2013, 62: 3103-3013.

Zhang Qian, Yu Junjie, Lv Ziquan, Liu Bin, Xia Tingting, Xiao Fei, Chen Shanghai, and Guo Feifan*. Central activating transcription factor (ATF4) regulates hepatic insulin resistance in mice via S6K1 signaling and the vagus nerve. Diabetes. 2013, 62: 2230-2239.

Xia Tingting, Cheng Ying, Zhang Qian, Xiao Fei, Liu Bin, Chen Shanghai, and Guo Feifan*. S6K1 in the central nervous system regulates energy expenditure via MC4R/corticotrophin -releasing hormone pathways in response to deprivation of an essential amino acid. Diabetes. 2012, 61: 2461-2471.

Xiao Fei, Huang Zhiying, Li Houkai, Yu Junjie, Wang Chunxia, Chen Shanghai, Meng Qingshu, Cheng Ying, Gao Xiang, Li Jia, Liu Yong, and Guo Feifan*. Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. Diabetes. 2011, 60:746-756.

Cheng Ying^#, Meng Qingshu^#, Wang Chunxia, Li Houkai, Huang Zhiying, Chen Shanghai, and Xiao Fei, Guo Feifan*. Leucine deprivation decreases fat mass by stimulation of lipolysis in WAT and upregulation of UCP1 in BAT. Diabetes. 2010, 59:17-25.

Wang Chunxia, Huang Zhiying, Du Ying, Cheng Ying, Chen Shanghai and Guo Feifan*. ATF4 regulates lipid metabolism and thermogenesis. Cell Research. 2010, 20:174–184. 

Jiang Xiaoxue, Xiao Fei and Guo Feifan*. Oocyte TET3: an epigenetic modifier responsible for maternal inheritance of glucose intolerance. Signal Transduction and Targeted Therapy. 2022 Oct 8;7(1):357. 

Jiang Xiaoxue, Xiao Fei and Guo Feifan*. Oocyte TET3: an epigenetic modifier responsible for maternal inheritance of glucose intolerance. Signal Transduction and Targeted Therapy. 2022 Oct 8;7(1):357.