炎症反应在机体发生病菌感染和组织损伤时发挥重要的防御作用,也与重大疾病密切相关,例如神经炎症几乎存在于所有神经退行性疾病中。课题组探究炎症相关信号通路的调控机制,包括离子通道和G蛋白偶联受体信号通路等方面,从分子水平追踪关键信号蛋白的动态性结构变化,并结合生物化学、神经生物学等手段阐明其与蛋白功能的关联,探究重要受体介导信号跨膜传输的作用机理,解析信号转导蛋白调控神经免疫系统通信和神经炎症的分子机制,并致力于特异性靶向药物设计。
邮箱:happyying0206@163.com
研究方向:实验室技术与管理
邮箱:22111520008@m.fudan.edu.cn
研究方向:神经炎症信号分子与其受体相互作用的分子机制
邮箱:22211520051@m.fudan.edu.cn
研究方向:神经炎症信号分子与其受体相互作用的分子机制
邮箱:zhoulin1632023@163.com
研究方向:神经炎症信号分子与其受体相互作用的分子机制
邮箱:23111520035@m.fudan.edu.cn
研究方向:神经炎症信号分子与其受体相互作用的分子机制
邮箱:23111210060@m.fudan.edu.cn
研究方向:胶质细胞与神经炎症
Zhang, K., Julius, D., and Cheng, Y. 2021. Structural snapshots of TRPV1 reveal mechanism of polymodal functionality, Cell, 184: 5138-5150 e12.
Zhang, K., Wu, H., Hoppe, N., Manglik, A., and Cheng, Y. 2022. Fusion protein strategies for cryo-EM study of G protein-coupled receptors, Nat Commun, 13: 4366.
Zhang, K.*, Zhang, J.*, Gao, Z.G., Zhang, D., Zhu, L., Han, G.W., Moss, S.M., Paoletta, S., Kiselev, E., Lu, W., Fenalti, G., Zhang, W., Muller, C.E., Yang, H., Jiang, H., Cherezov, V., Katritch, V., Jacobson, K.A., Stevens, R.C., Wu, B., and Zhao, Q. 2014. Structure of the human P2Y12 receptor in complex with an antithrombotic drug, Nature, 509: 115-8. (*, co-first author)
Zhang, J.*, Zhang, K.*, Gao, Z.G., Paoletta, S., Zhang, D., Han, G.W., Li, T., Ma, L., Zhang, W., Muller, C.E., Yang, H., Jiang, H., Cherezov, V., Katritch, V., Jacobson, K.A., Stevens, R.C., Wu, B., and Zhao, Q. 2014. Agonist-bound structure of the human P2Y12 receptor, Nature, 509: 119-22. (*, co-first author)
Zhang, K., Julius, D., and Cheng, Y. 2022. A step-by-step protocol for capturing conformational snapshots of ligand gated ion channels by single-particle cryo-EM, STAR Protoc, 3: 101732.
Zhou, X.X., Bracken, C.J., Zhang, K., Zhou, J., Mou, Y., Wang, L., Cheng, Y., Leung, K.K., and Wells, J.A. 2020. Targeting Phosphotyrosine in Native Proteins with Conditional, Bispecific Antibody Traps, J Am Chem Soc, 142: 17703-17713.
Schoof, M., Faust, B., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesbolle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Deshpande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Consortium, Q.S.B., Walter, P., and Manglik, A. 2020. An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike, Science, 370: 1473-1479.
Faust, B., Billesbolle, C.B., Suomivuori, C.M., Singh, I., Zhang, K., Hoppe, N., Pinto, A.F.M., Diedrich, J.K., Muftuoglu, Y., Szkudlinski, M.W., Saghatelian, A., Dror, R.O., Cheng, Y., and Manglik, A. 2022. Autoantibody mimicry of hormone action at the thyrotropin receptor, Nature, 609: 846-853.
Zhang, D., Gao, Z.G., Zhang, K., Kiselev, E., Crane, S., Wang, J., Paoletta, S., Yi, C., Ma, L., Zhang, W., Han, G.W., Liu, H., Cherezov, V., Katritch, V., Jiang, H., Stevens, R.C., Jacobson, K.A., Zhao, Q., and Wu, B. 2015. Two disparate ligand-binding sites in the human P2Y1 receptor, Nature, 520: 317-21.
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