The editing scopes of CBEs were defined as cytosine (C) positions with ≥40% editing frequency. (a) Forward-shifted CBEs (FSCBEs) display editing scopes in the forward region of target DNA (PAM region as the terminus). (b) Backward-shifted CBEs (BSCBEs) display editing scopes in the backward region of target DNA. (c) Broad-range CBEs (BRCBEs) display editing scopes across the forward and backward regions of target DNA.
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