1）The technology and mechanism of somatic cell reprogramming
2）The pathogenesis of schizophrenia
3）Brain Organoid-on-a-Chip and neural regeneration
Email:wwxue@fudan.edu.cn
Research Direction:1. Central nerve regeneration 2. Organoid and spinal cord injury repair
Email:huihuiliu03@163.com
Research Direction:Not yet
Email:jellyfish923@outlook.com
Research Direction:GABA organoid transplantation
Email:22211520013@m.fudan.edu.cn
Research Direction:epilepsy patient organoid
Email:jcdu22@m.fudan.edu.cn
Research Direction:Spinal cord organoid chip and spinal cord injury repair
Email:yb67622@um.edu.mo
Research Direction:Spinal cord organoid chip and spinal cord injury repair
Email:bioinfolhj@163.com
Research Direction:Genetic analysis of schizophrenia
Email:zhuxiaofeng_2012@163.com
Research Direction:Research of organoid models and schizophrenia
Email:1593860167@qq.com
Research Direction:The role of small molecule compounds in promoting somatic cell reprogramming
Email:1186940451@qq.com
Research Direction:Pathogenesis of schizophrenia
Email:20211520021@fudan.edu.en
Research Direction:Pathogenesis of epilepsy
Email:1341483861@qq.com
Research Direction:Culture 3D spinal cord organoids and skeletal muscle organoids in vitro
Email:xmublee@foxmail.com
Research Direction:Construction of 3D spinal cord organoids
Email:272784898@qq.com
Research Direction:Reprogramming of glial cells
Weiwei Xue#*, Bo Li#, Huihui Liu#, Yujie Xiao, Bo Li, Lei Ren, Huijuan Li, Zhicheng Shao*. Generation of Dorsoventral Human Spinal Cord Organoids via Functionalizing Composite Scaffold for Drug Testing. iScience, 2023, 26, 105898
Xu J.#; Fang S; Wang N.; Li B; Huang Y.; Fan Q; Shi J.; Liu H.; Shao Z.*, Dual‑specifcity Tyrosine Phosphorylation‑regulated Kinase Inhibitor ID‑8 Promotes Human Somatic Cell Reprogramming by Activating PDK4 Expression. Stem Cell Reviews and Reports (2022) 18:2074–2087
Xu J.#; Fang S#; Deng S.; Li H.; Lin X.; Huang Y.; Chung S.; Shu Y.; Shao Z.*, Generation of neural organoids for spinal-cord regeneration via the direct reprogramming of human astrocytes. Nature Biomedical Engineering 2022, doi.org/10.1038/s41551-022-00963-6 (online)
Shao Z, Cevallos RR, and Hu K，Reprogramming Human Fibroblasts to Induced Pluripotent Stem Cells Using
the GFP-Marked Lentiviral Vectors in the Chemically Defined Medium. (from Book,Kejin Hu (ed.), Nuclear Reprogramming:
Methods and Protocols, Methods in Molecular Biology, vol. 2239, Chapter 7，© Springer Science+Business Media, LLC, part of Springer Nature 2021)
Zhao, J#.; Ye, Z#.; Yang, J#.; Zhang, Q.; Shan, W.; Wang, X.; Wang, Z.; Ye, S.; Zhou, X.; Shao, Z*.; Ren, L*., Nanocage encapsulation improves antiepileptic efficiency of phenytoin. Biomaterials 2020, 240, 119849.
Park G.; Noh H.; Shao Z.; Ni P.; QinY.; Liu D.; Beaudreault C.; Park J.; Abani C.; ParkJ.; Le D.; Gonzalez S.; Guan Y.; Cohen B.; McPhie D.; Coyle J.; Lanz T.; Xi H.; Yin C.; Huang W.; Kim H.; Chung S., Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia. Nature neuroscience 2020, 23, 1352-1364.
Zeng, F#.; Ma, X#.; Zhu, L.; Xu, Q.; Zeng, Y.; Gao, Y.; Li, G.; Guo, T.; Zhang, H.; Tang, X.; Wang, Z.; Ye, Z.; Zheng, L.; Zhang, H.; Zheng, Q.; Li, K.; Lu, J.; Qi, X.; Luo, H.; Zhang, X.; Wang, Z.; Zhou, Y.; Yao, Y.; Ke, R.; Zhou, Y.; Liu, Y.; Sun, H.; Huang, T.; Shao, Z.; Xu, H.; Wang, X*., The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability. PLoS Biol 2019, 17 (12), e3000525.
Shao, Z#.; Noh, H#.; Bin Kim, W.; Ni, P.; Nguyen, C.; Cote, S. E.; Noyes, E.; Zhao, J.; Parsons, T.; Park, J. M.; Zheng, K.; Park, J. J.; Coyle, J. T.; Weinberger, D. R.; Straub, R. E.; Berman, K. F.; Apud, J.; Ongur, D.; Cohen, B. M.; McPhie, D. L.; Rapoport, J. L.; Perlis, R. H.; Lanz, T. A.; Xi, H. S.; Yin, C.; Huang, W.; Hirayama, T.; Fukuda, E.; Yagi, T.; Ghosh, S.; Eggan, K. C.; Kim, H. Y.; Eisenberg, L. M.; Moghadam, A. A.; Stanton, P. K.; Cho, J. H*.; Chung, S*., Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia. Nat Neurosci 2019, 22 (2), 229-242.
Ni, P.; Noh, H.; Shao, Z.; Zhu, Q.; Guan, Y.; Park, J. J.; Arif, F.; Park, J. M.; Abani, C.; Beaudreault, C.; Park, J. S.; Berry, E.; Moghadam, A.; Stanton, P.; Hutchinson, J. N.; Andrews, B.; Faux, C.; Parnevelas, J.; Eisenberg, L. M.; Park, K.; Bolshakov, V. Y.; Chung, S*., Large-Scale Generation and Characterization of Homogeneous Populations of Migratory Cortical Interneurons from Human Pluripotent Stem Cells. Mol Ther Methods Clin Dev 2019, 13, 414-430.
Ni, P#.; Noh, H#.; Park, G. H.; Shao, Z.; Guan, Y.; Park, J. M.; Yu, S.; Park, J. S.; Coyle, J. T.; Weinberger, D. R.; Straub, R. E.; Cohen, B. M.; McPhie, D. L.; Yin, C.; Huang, W.; Kim, H. Y.; Chung, S*., iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function. Mol Psychiatry 2019.
Leng, L#.; Zhuang, K#.; Liu, Z.; Huang, C.; Gao, Y.; Chen, G.; Lin, H.; Hu, Y.; Wu, D.; Shi, M.; Xie, W.; Sun, H.; Shao, Z.; Li, H.; Zhang, K.; Mo, W.; Huang, T. Y.; Xue, M.; Yuan, Z.; Zhang, X.; Bu, G.; Xu, H.; Xu, Q*.; Zhang, J*., Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation. Neuron 2018, 100 (3), 551-563 e7.
Noh, H#.; Shao, Z#.; Coyle, J. T.; Chung, S*., Modeling schizophrenia pathogenesis using patient-derived induced pluripotent stem cells (iPSCs). Biochim Biophys Acta Mol Basis Dis 2017, 1863 (9), 2382-2387.
Shao, Z.; Zhang, R.; Khodadadi-Jamayran, A.; Chen, B.; Crowley, M. R.; Festok, M. A.; Crossman, D. K.; Townes, T. M.; Hu, K*., The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis. Nat Commun 2016, 7, 10869.
Shao, Z#.; Yao, C#.; Khodadadi-Jamayran, A#.; Xu, W.; Townes, T. M.; Crowley, M. R.; Hu, K*., Reprogramming by De-bookmarking the Somatic Transcriptional Program through Targeting of BET Bromodomains. Cell Rep 2016, 16 (12), 3138-3145.
Shao, Z.; Luo, Q.; Liu, D.; Mi, Y.; Zhang, P.; Ju, G*., Induced differentiation of neural stem cells of astrocytic origin to motor neurons in the rat. Stem Cells Dev 2011, 20 (7), 1163-70.
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Email: zcshao@fudan.edu.en
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