The research titled "Presynaptic endosomal Cathepsin D regulates the biogenesis of GABAergic synaptic vesicles" was published online in "Cell Reports" on July 23, 2019. Through confocal and ultra-high resolution fluorescent imaging technology, it found that the lysosomal proteolytic enzyme cathepsin D is selectively distributed in GABAergic presynaptic endosomes and regulates the regeneration of GABAergic synaptic vesicles and synaptic transmission. Interestingly, cathepsin D mutations can lead to a clinically disease called "lysosomal storage disease", which can cause functional degeneration and abnormalities of nervous system and other organs. This study found for the first time that the functional defects of cathepsin D can lead to the abnormal function of GABAergic presynaptic endocytosis, and then selectively damage the function of GABAergic synapses. The research provided the explanation for the neuropathy of nervous system excitation-inhibition imbalance in cathepsin D-related diseases.
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