My laboratory focuses on the translational study of central nervous system (CNS) tumors and inflammation, especially in characterizing dynamic evolution of disease and developing novel therapeutic strategies on targeting microenvironment. We employ whole-genome sequencing, single-cell transcriptome sequencing, and metabolomics analysis to further investigate the microenvironmental effects on the CNS. Taking advantage of experimental mouse models with CNS tumors and inflammation, we will explore the biological function, efficiency and safety of new targets for early-phase clinical trials.
1. The dynamic in CNS tumors and inflammation
2. Metabolic reprogramming in tumor microenvironment.
3. Mechanism of CNS tumors and inflammation inducing intracranial damage
4. Biomarker identification and biological function in cerebral spinal fluid.
Email:hbpeng@fudan.edu.cn
Research Direction:Central Nervous System Drug Delivery, Biomimetic Nanomedicine, Stimulus Responsive Functional Materials
Email:14111520012@fudan.edu.cn
Research Direction:Investigation of the mechanism involved in cancer dural metastasis； The investigation of the vital factors involved in the development of lung cancer leptomeningeal metastasis and targeted therapy
Email:jiaxuzhao@fudan.edu.cn
Research Direction:Meningeal metastasis and immune microenvironment
Email: huang_yang@fudan.edu.cn
Research Direction:The role and regulatory mechanism of exosomes in brain metastases
Email:646825836@qq.com
Research Direction:not
Email:joyezhang313@163.com
Research Direction:Metabolic reprogramming in central nervous system tumors
Email:22111520003@m.fudan.edu.cn
Research Direction:Functional studies of stem cells in brain metastasis
Email:21211520016@m.fudan.edu.cn
Research Direction:Cell motility and immunology research of leptomeningeal metastasis
Email:rzeng18@fudan.edu.cn
Research Direction:immune microenvironment remodulation in LM
Email:19301050186@fudan.edu.cn
Research Direction:Targeted Therapies for Tumor Microenvironment
Email:20301050279@fudan.edu.cn
Research Direction:leptomeningeal metastasis
Email:20301020104@fudan.edu.cn
Research Direction:Interactions between dural macrophages and tumor cells in meningeal metastases
Email:21301050205@m.fudan.edu.cn
Research Direction:Roles of exosomes in leptomeningeal metastasis
Pan L#, Peng H#, Lee B, Zhao J, Shen X, Yan X, Hua Y, Kim J, Kim D, Lin M, Zhang S, Li X, Yi X, Yao F, Qin Z, Du J, Chi Y*, Nam J*, Hyeon T*, Liu J *(2023). Cascade Catalytic Nanoparticles Selectively Alkalize Cancerous Lysosomes to Suppress Cancer Progression and Metastasis. Advanced Materials, Online
Peng H, Yao F, Zhao J, Zhang W, Chen L, Wang X, Yang P*, Tang J*, Chi Y* (2023). Unraveling mitochondria-targeting reactive oxygen species modulation and their implementations in cancer therapy by nanomaterials. Exploration, 3(2):20220115
Chi Y, Wang X, Yang Y, Zhang C, Ertl HC, Zhou D*(2014). Survivin-targeting Artificial MicroRNAs Mediated by Adenovirus Suppress Tumor Activity in Cancer Cells and Xenograft Models. Mol Ther Nucleic Acids, 3(11):e208.
Zhang C, Yang Y, Chi Y, Yin J, Yan L, Ku Z, Liu Q, Huang Z, Zhou D*(2015). Hexon-modified recombinant E1-deleted adenoviral vectors as bivalent vaccine carriers for Coxsackievirus A16 and Enterovirus 71. Vaccine, 33(39):5087-94
Yang Y, Chi Y, Tang X, Ertl HCJ, Zhou D*(2016). Rapid, Efficient, and Modular Generation of Adenoviral Vectors via Isothermal Assembly. Curr Protoc Mol Biol, 113(1):16.26.1-16.26.18.
Xing M, Wang X, Chi Y, Zhou D* (2016). Gene therapy for colorectal cancer using adenovirus-mediated full-length antibody, cetuximab. Oncotarget, 7(19):28262-72.
Chi Y, Zhou D*(2016). MicroRNAs in colorectal carcinoma--from pathogenesis to therapy. J Exp Clin Cancer Res, 10;35:43.
Cheng T, Song Y, Zhang Y, Zhang C, Yin J, Chi Y, Zhou D*(2017). A novel oncolytic adenovirus based on simian adenovirus serotype 24. Oncotarget, 8(16):26871-26885.
Wang X, Fu W, Yuan S, Yang X, Song Y, Liu L, Chi Y, Cheng T, Xing M, Zhang Y, Zhang C, Yang Y, Zhu C, Zhang X, Xiong S, Xu J, Zhou D*(2017). Both haemagglutinin-specific antibody and T cell responses induced by a chimpanzee adenoviral vaccine confer protection against influenza H7N9 viral challenge. Sci Rep, 7(1):1854.
Zhang C, Chi Y, Zhou D*(2017). Development of Novel Vaccines Against Infectious Diseases Based on Chimpanzee Adenoviral Vector. Methods Mol Biol, 1581:3-13.
Zhang G, Chi Y, Du YN*(2017). Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model. J Vis Exp, (128):55890.
Wang X, Fang Z, Xiong J, Yang K, Chi Y, Tang X, Ma L, Zhang R, Deng F, Lan K, Zhou D*(2019). A chimpanzee adenoviral vector-based rabies vaccine protects beagle dogs from lethal rabies virus challenge. Virology, 536:32-38.
Zhang T, Choi S, Zhang T, Chen Z, Chi Y, Huang S, Xiang JZ, Du YN*(2020). miR-431 Promotes Metastasis of Pancreatic Neuroendocrine Tumors by Targeting DAB2 Interacting Protein, a Ras GTPase Activating Protein Tumor Suppressor. Am J Pathol, 190(3):689-701
Remsik J, Chi Y, Tong X, Sener U, Derderian C, Park A, Saadeh F, Bale T, Boire A*(2020) Leptomeningeal metastatic cells adopt two phenotypic states. Cancer Reports, e1236.
Chi Y, Remsik J, Kiseliovas V, Derderian C, Sener U, Alghader M, Saadeh F, Nikishina K, Bale T, Iacobuzio-Donahue C, Thomas T, Pe'er D, Mazutis L, Boire A*(2020). Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis. Science, 369(6501):276-282.
Address: Floor 2, Building B, Medical Research Building, 131 Dong'an Road, Xuhui District, Shanghai
Postcode: 200032
Telephone/Fax: 021-54237056
Email: chiy@fudan.edu.cn
Address:No.138, medical college road 
Postcode:200032 
Tel/Fax:021-54237056
Emial:itbr@fudan.edu.cn220 Handan Rd., Shanghai(200433) Operator：+86-21-65642222 © 2019 FUDAN UNIVERSITY.
