Weisheng Wang-INSTITUTE FOR TRANSLATIONAL BRAIN RESEARCH

Weisheng Wang

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Weisheng Wang Principal Investigator

Neural Circuitry and Molecular Mechanisms of Negative Affect and Related Disorders

Weisheng Wang, Investigator (Professor) at the Institute for Translational Brain Research, Fudan University. He received his Ph.D. from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences in 2011. From 2011 to 2013, he served as an Assistant Investigator at the Shanghai Institute of Materia Medica, CAS. From 2013 to 2021, he was a Postdoctoral Researcher and Project Scientist at the University of California, USA. He joined the Institute for Translational Brain Research at Fudan University in August 2021. Prof. Wang is a recipient of the NARSAD Young Investigator Grant. He has been awarded funding from the National Natural Science Foundation of China (Young Scientists Fund, General Program) and the Brain & Behavior Research Foundation (USA), and participates in the "Brain Science and Brain-Like Intelligence Technology" major project under the National Science and Technology Innovation 2030 Initiative. His primary research focuses on the neural circuitry and plasticity mechanisms underlying negative affect and related disorders, with a particular emphasis on panic disorder, autism, and peripheral diseases linked to emotional states. His work aims to elucidate the pathological mechanisms of neuropsychiatric disorders and explore potential therapeutic strategies. His works have been published in academic journals such as Nature Communications, Neuron, Molecular Psychiatry, and eLife et al.

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The research group primarily employs viral circuit tracing, optogenetics/chemogenetics, miniscope , neuromodulator sensor, and novel behavioral paradigms to investigate how neurons and neural circuits to control and encode the emotion-related behaviors. The group explores the top-down regulatory mechanisms by which prior experiences and internal bodily states influence the initiation and development of instinctive behaviors, and their pathological roles in the onset and progression of related psychiatric disorders. Furthermore, the group aims to elucidate the neural circuitry and molecular mechanisms underlying peripheral diseases (such as gastrointestinal disorders and tumors) regulated by negative affect. Research projects include: 1) Investigation of the pathological neural circuit mechanisms underlying panic disorder and its somatic symptoms. 2) Study of the neural circuit mechanisms by which emotion regulates instinctive behaviors (such as self-grooming, social interaction, empathy, etc.), and neural modulation research for related psychiatric disorders. 3) Investigation of the neural circuitry and molecular mechanisms underlying peripheral diseases (such as gastrointestinal disorders and tumors) triggered by emotional states.