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NeuroD1不能诱导小胶质细胞至神经元的转分化

Date:2021-12-17 ClickTimes: SourceLink:

NeuroD1不能诱导小胶质细胞至神经元的转分化,前人所观察到的所谓“转分化”现象源自于病毒非特异性泄露和实验假象。相反,NeuroD1通过BCL2途径诱导小胶质细胞凋亡。

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Rao Y.*, Du S., Yang B., Wang Y., Li Y., Li R., Zhou T., Du X., He Y., Wang Y., Zhou X., Yuan T.-F.*, Mao Y.* andPeng B.*(2021) NeuroD1 induces microglial apoptosis and cannot induce microglia-to-neuron cross-lineage reprogramming,Neuron109, 4094-4108.e4095.

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