Tianlin Cheng
Junior Principal Investigator
Tianlin Cheng
Dr. Tian-Lin Cheng got his bachelor degree in 2008 from Fudan University, and received his Ph.D. degrees from Institute of Neuroscience, Chinese Academy of Sciences in 2014. From 2014 to 2019, he worked as Assistant Investigator in Dr. Zilong Qiu’s lab at Institute of Neuroscience, Chinese Academy of Sciences. He joined Institute for Translational Brain Research at Fudan University in January 2020 as Junior Principal Investigator. He mainly focuses on the development of novel gene editing tools and gene therapy for genetic disorders.
CRISPR-Cas systems have revolutionized gene editing researches and represent promising techniques for gene therapy. However, CRISPR-based tools still face great challenges including restricted activity windows, off-target effects andin vivodelivery efficiencies. Here we focus on the development of novel gene editing tools and improvement of available CRISPR-based tools to expand their applications. We also focus on their potential applications as gene therapy tools for genetic diseases and will assess the therapeutic effects using mouse models of neurodevelopmental disorders.
Email:fudanliweike@fudan.edu.cn
Research Direction:Development and Optimization of Gene Editing Tools, Animal Model Construction, and Gene Therapy.
Email:zhangqianwei2022@163.com
Research Direction:Laboratory Management Responsibilities
Email:22111520006@m.fudan.edu.cn
Research Direction:Development, Optimization, and Application of Gene Editing Tools.
Email:23111520006@m.fudan.edu.cn
Research Direction:Development of Novel Gene Editing Tools and Gene Therapy for Neurological Disorders.
Email:fudanczhang@163.com
Research Direction:Development and Optimization of the Gene Editing Tool CRISPR, and Its Application in Neurological Disorders.
Email:23211520054@m.fudan.edu.cn
Research Direction:Development and Application of Gene Editing Tools.
Email:22211520017@m.fudan.edu.cn
Research Direction:Development, Optimization, and Application of Gene Editing Tools.
Email:zhang.shuqian@163.com
Research Direction:Development of Novel Gene Editing Tools and Gene Therapy for Neurological Diseases.
Wei-Ke Li#, Shu-Qian Zhang#, Wan-Ling Peng, Yu-Han Shi, Bo Yuan, Yi-Ting Yuan, Zhen-Yu Xue, Jin-Cheng Wang, Wen-Jian Han, Zhi-Fang Chen, Shi-Fang Shan, Bi-Qing Xue, Jin-Long Chen, Cheng Zhang, Shu-Jia Zhu, Yi-Lin Tai, Min Xu, Tian-Lin Cheng*, Zi-Long Qiu*, Whole-brain in vivo base editing reverses behavioral changes in Mef2c-mutant mice, Nature Neuroscience, 2024, 27, 116–128
Bo Yuan#, Shuqian Zhang#, Liting Song#, Jinlong Chen, Jixin Cao, Jiayi Qiu, Zilong Qiu, Jingqi Chen*, Xing-Ming Zhao*, Tian-Lin Cheng*, Engineering of cytosine base editors with DNA damage minimization and editing scope diversification, Nucleic Acids Research, 2023, gkad855
Li Shuo, Bo Yuan, Jixin Cao, Jingqi Chen, Jinlong Chen, Jiayi Qiu, Xing-Ming Zhao, Xiaolin Wang*, Zilong Qiu*, Tian-Lin Cheng* (2020). Docking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination, Nature Communications, 11:5827.
Tian-Lin Cheng*, Shuo Li, Bo Yuan, Xiaolin Wang, Wenhao Zhou, Zilong Qiu* (2019). Expanding C-T base editing toolkit with diversified cytidine deaminases, Nature Communications, 10:3612
Yuan Cai#,Tianlin Cheng#,Yichuan Yao#, Xiao Li, Yuqian Ma, Lingyun Li, Huan Zhao, Jin Bao, Mei Zhang*, Zilong Qiu*, Tian Xue*(2019). In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway, Science Advances, eaav3335
Tian-Lin Cheng*, Zilong Qiu*(2019). Long non-coding RNA tagging and expression manipulation via CRISPR/Cas9-mediated targeted insertion, Protein Cell, 9: 820
Ling-jie He#, Nan Liu#, Tian-lin Cheng, Xiao-jing Chen, Yi-ding Li, Yousheng Shu, Zilong Qiu, and Xiaohui Zhang(2014). Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in absence of critical period plasticity, Nature communications, 5:5036
Tian-Lin Cheng, Zhizhi Wang, Qiuming Liao, Ying Zhu, Wen-Hao Zhou, Wenqing Xu, Zilong Qiu*(2014). MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex, Developmental Cell, 28:547-560
Address: Floor 2, Building B, Medical Research Building, 131 Dong
Postcode: 200032
Email: chengtianlin@fudan.edu.cn
Address:No.138, medical college road 
Postcode:200032 
Tel/Fax:021-54237056
Emial:itbr@fudan.edu.cn220 Handan Rd., Shanghai(200433) Operator：+86-21-65642222 © 2019 FUDAN UNIVERSITY.
