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小胶质细胞碎片的清除机制

Date:2022-09-05 ClickTimes: SourceLink:

小胶质细胞碎片通过C4b介导的途径,被星形胶质细胞(astrocyte)和穆勒胶质细胞(Müller glia)清除,并通过RUBICON依赖的非经典自噬途径降解。

Zhou T., Li Y., Li X., Zeng F., Rao Y., He Y., Wang Y., Liu M., Li D., Xu Z., Zhou X., Du S., Niu F., Peng J., Mei X., Ji S.-J., Shu Y., Lu W., Guo F., Wu T., Yuan T.-F., Mao Y. and Peng B.* (2022) Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent non-canonical autophagy. Nature Communications (in press).


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