Tianlin Cheng-INSTITUTE FOR TRANSLATIONAL BRAIN RESEARCH

Tianlin Cheng

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Tianlin Cheng Principal Investigator

Gene Editing Techniques & Gene Therapy for Genetic Brain Disorders

Dr. Tian-Lin Cheng got his bachelor degree in 2008 from Fudan University, and received his Ph.D. degrees from Institute of Neuroscience, Chinese Academy of Sciences in 2014. From 2014 to 2019, he worked as Assistant Investigator in Dr. Zilong Qiu's lab at Institute of Neuroscience, Chinese Academy of Sciences. He joined Institute for Translational Brain Research at Fudan University in January 2020 as Junior Principal Investigator. He mainly focuses on the development of novel gene editing tools and gene therapy for genetic disorders.

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CRISPR-Cas systems have revolutionized gene editing researches and represent promising techniques for gene therapy. However, CRISPR-based tools still face great challenges including restricted activity windows, off-target effects andin vivodelivery efficiencies. Here we focus on the development of novel gene editing tools and improvement of available CRISPR-based tools to expand their applications. We also focus on their potential applications as gene therapy tools for genetic diseases and will assess the therapeutic effects using mouse models of neurodevelopmental disorders.