My laboratory focuses on the translational study of central nervous system (CNS) tumors and inflammation, especially in characterizing dynamic evolution of disease and developing novel therapeutic strategies on targeting microenvironment. We employ whole-genome sequencing, single-cell transcriptome sequencing, and metabolomics analysis to further investigate the microenvironmental effects on the CNS. Taking advantage of experimental mouse models with CNS tumors and inflammation, we will explore the biological function, efficiency and safety of new targets for early-phase clinical trials.
1. The dynamic in CNS tumors and inflammation
2. Metabolic reprogramming in tumor microenvironment.
3. Mechanism of CNS tumors and inflammation inducing intracranial damage
4. Biomarker identification and biological function in cerebral spinal fluid.
Email:hbpeng@fudan.edu.cn
Research Direction:Central Nervous System Drug Delivery, Biomimetic Nanomedicine, Stimulus Responsive Functional Materials
Email:14111520012@fudan.edu.cn
Research Direction:Investigation of the mechanism involved in cancer dural metastasis； The investigation of the vital factors involved in the development of lung cancer leptomeningeal metastasis and targeted therapy
Email:jiaxuzhao@fudan.edu.cn
Research Direction:Meningeal metastasis and immune microenvironment
Email: huang_yang@fudan.edu.cn
Research Direction:The role and regulatory mechanism of exosomes in brain metastases
Email:646825836@qq.com
Research Direction:not
Email:joyezhang313@163.com
Research Direction:Metabolic reprogramming in central nervous system tumors
Email:22111520003@m.fudan.edu.cn
Research Direction:Functional studies of stem cells in brain metastasis
Email:21211520016@m.fudan.edu.cn
Research Direction:Cell motility and immunology research of leptomeningeal metastasis
Email:rzeng18@fudan.edu.cn
Research Direction:immune microenvironment remodulation in LM
Email:19301050186@fudan.edu.cn
Research Direction:Targeted Therapies for Tumor Microenvironment
Email:20301050279@fudan.edu.cn
Research Direction:leptomeningeal metastasis
Email:20301020104@fudan.edu.cn
Research Direction:Interactions between dural macrophages and tumor cells in meningeal metastases
Email:21301050205@m.fudan.edu.cn
Research Direction:Roles of exosomes in leptomeningeal metastasis
Fu M#, Zhao J#, Zhang L, Sheng Z, Li X, Qiu F, Feng Y, You M, Xu H, Zhang J, Zeng R, Huang Y, Li C, Chen W, Chen Z, Peng H, Li L, Wu Y, Ye D, Chi Y *, Hua W*, Mao Y*. Overcoming Tyrosine Kinase Inhibitor Resistance in Lung Cancer Brain Metastasis with CTLA4 Blockade. Cancer Cell, 2024 Oct 9:S1535-6108(24)00360-X
Pan L#, Peng H#, Lee B, Zhao J, Shen X, Yan X, Hua Y, Kim J, Kim D, Lin M, Zhang S, Li X, Yi X, Yao F, Qin Z, Du J, Chi Y*, Nam J*, Hyeon T*, Liu J* (2024). Cascade Catalytic Nanoparticles Selectively Alkalize Cancerous Lysosomes to Suppress Cancer Progression and Metastasis. Advanced Materials, 36(5):e2305394.
Peng H, Yao F, Zhao J, Zhang W, Chen L, Wang X, Yang P*, Tang J*, Chi Y* (2023). Unraveling mitochondria-targeting reactive oxygen species modulation and their implementations in cancer therapy by nanomaterials. Exploration, 3(2):20220115
Chi Y, Remsik J, Kiseliovas V, Derderian C, Sener U, Alghader M, Saadeh F, Nikishina K, Bale T, Iacobuzio-Donahue C, Thomas T, Pe'er D, Mazutis L, Boire A*(2020). Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis. Science, 369(6501):276-282.
Remsik J, Chi Y, Tong X, Sener U, Derderian C, Park A, Saadeh F, Bale T, Boire A*(2020) Leptomeningeal metastatic cells adopt two phenotypic states. Cancer Reports, e1236.
Zhang T, Choi S, Zhang T, Chen Z, Chi Y, Huang S, Xiang JZ, Du YN*(2020). miR-431 Promotes Metastasis of Pancreatic Neuroendocrine Tumors by Targeting DAB2 Interacting Protein, a Ras GTPase Activating Protein Tumor Suppressor. Am J Pathol, 190(3):689-701
Zhang G, Chi Y, Du YN*(2017). Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model. J Vis Exp, (128):55890.
Chi Y, Zhou D*(2016). MicroRNAs in colorectal carcinoma--from pathogenesis to therapy. J Exp Clin Cancer Res, 10;35:43.
Yang Y, Chi Y, Tang X, Ertl HCJ, Zhou D*(2016). Rapid, Efficient, and Modular Generation of Adenoviral Vectors via Isothermal Assembly. Curr Protoc Mol Biol, 113(1):16.26.1-16.26.18.
Chi Y, Wang X, Yang Y, Zhang C, Ertl HC, Zhou D*(2014). Survivin-targeting Artificial MicroRNAs Mediated by Adenovirus Suppress Tumor Activity in Cancer Cells and Xenograft Models. Mol Ther Nucleic Acids, 3(11):e208.
Address: Floor 2, Building B, Medical Research Building, 131 Dong'an Road, Xuhui District, Shanghai
Postcode: 200032
Telephone/Fax: 021-54237056
Email: chiy@fudan.edu.cn
Address:No.138, medical college road 
Postcode:200032 
Tel/Fax:021-54237056
Emial:itbr@fudan.edu.cn220 Handan Rd., Shanghai(200433) Operator：+86-21-65642222 © 2019 FUDAN UNIVERSITY.
