My laboratory focuses on the translational study of central nervous system (CNS) tumors and inflammation, especially in characterizing dynamic evolution of disease and developing novel therapeutic strategies on targeting microenvironment. We employ whole-genome sequencing, single-cell transcriptome sequencing, and metabolomics analysis to further investigate the microenvironmental effects on the CNS. Taking advantage of experimental mouse models with CNS tumors and inflammation, we will explore the biological function, efficiency and safety of new targets for early-phase clinical trials.
1. The dynamic in CNS tumors and inflammation
2. Metabolic reprogramming in tumor microenvironment.
3. Mechanism of CNS tumors and inflammation inducing intracranial damage
4. Biomarker identification and biological function in cerebral spinal fluid.
Email:hbpeng@fudan.edu.cn
Research Direction:Central Nervous System Drug Delivery, Biomimetic Nanomedicine, Stimulus Responsive Functional Materials
Email:huang_yang@fudan.edu.cn
Research Direction:The role and regulatory mechanism of exosomes in brain metastases
Email:noorulain@fudan.edu.cn
Research Direction:Novel Strategies for Treating Leptomeningeal Metastasis.
Email:646825836@qq.com
Research Direction:not
Email:21211520016@m.fudan.edu.cn
Research Direction:Cell motility and immunology research of leptomeningeal metastasis
Email:24111530017@m.fudan.edu.cn
Research Direction:Meningeal metastasis and immune microenvironment
Email:24211530009@m.fudan.edu.cn
Research Direction:Drug delivery in the central nervous system
Email:21301050205@m.fudan.edu.cn
Research Direction:Roles of exosomes in leptomeningeal metastasis
Email:20301010028@fudan.edu.cn
Research Direction:Mechanism Research on Tumor Microenvironment of Brain Metastases
Email:23301020074@m.fudan.edu.cn
Research Direction:The phenomenon of cell aggregation in the cerebrospinal fluid microenvironment and the mechanism of cancer development
Email:24301050249@m.fudan.edu.cn
Research Direction:The tumor microenvironment of pial metastases
Email:24301050332@m.fudan.edu.cn
Research Direction:none
Email:21301050187@m.fudan.edu.cn
Research Direction:Drug delivery of central neural system
Email:rzeng18@fudan.edu.cn
Research Direction:immune microenvironment remodulation in LM
Email:yusl19@fudan.edu.cn
Research Direction:The impact of radiotherapy on immune system in brain metastases
Email:14111520012@fudan.edu.cn
Research Direction:Investigation of the mechanism involved in cancer dural metastasis； The investigation of the vital factors involved in the development of lung cancer leptomeningeal metastasis and targeted therapy
Email:zhangw7019@163.com
Research Direction:Mechanism of brain vascular disease development
Email:22111520003@m.fudan.edu.cn
Research Direction:Functional studies of stem cells in brain metastasis
Email:chenhr18@fudan.edu.cn
Research Direction:Mechanism Research on Tumor Microenvironment of Brain Metastases
Email:shen.yang4@zs-hospital.sh.cn
Research Direction:Central Nervous System Drug Delivery、Stimuli-Responsive Functional Materials
Email:19301050186@fudan.edu.cn
Research Direction:Targeted Therapies for Tumor Microenvironment
Email:20301050279@fudan.edu.cn
Research Direction:leptomeningeal metastasis
Email:20301020104@fudan.edu.cn
Research Direction:Interactions between dural macrophages and tumor cells in meningeal metastases
Lab Alumni
Email:
Research Direction:Meningeal metastasis and immune microenvironment
Email:
Research Direction:Research direction：Metabolic reprogramming in central nervous system tumorsEducation2018-2021, China Pharmaceutical University, M.S, Supervisor: Prof. Yong Yang2014-2018, Shihezi University, Pharmacy, B.SPublicationsYe Zhang#; Xue Yang#; Wenchao Yan; Rui Li; Qian Ye; Linjun You; Wenhao Xie; Kun Mo; Ruifeng Fu; Yanxiang Wang; Yufei Chen; Hui Hou; Yong Yang ; Lutz Birnbaumer* & Qin Di* & Xianjing Li*...
Huang Y#, Hou Y#, Yang J, Yang W, Liu H, Peng H, Li X, Zhao J, Zhang Y, Zeng R, Zeng Y, Li C, Zhang Q, Chi Y*. Leptomeningeal metastatic cancers trigger formation of a pre-metastatic niche within the choroid plexus through an extracellular vesicle-derived metabolite. Nature Cancer, 2026
Peng H#, Zeng Y#, Huang Y#, Lin C, Lei Z, Sun P, Yang J, Sheng S, Huang Y, Li X, Zhao J, Zeng R, Li C, Yang W, Di X, He S, Wang Y, Yang H*, Yang W*, Chi Y* Engineered Zwitterion-Nanodelivery for Precision Targeting of Brain Metastases. Nature Communications, 2026
Li G, Zhang H, Wang B, Chen J, Yang J, Yu G, Quan K, Li S, Liu Y, Shi Y, Li Z, Hu L, Liu M, Pan T, Shen S, Dong X, Li P, Qiu T, Liu P, Chi Y*, Zhu W*. Multi-omics analysis reveals NSUN2-mediated m5C methylation of DOCK9 regulating vascular stability in brain arteriovenous malformations. Cell Reports, 2026
Zhang Y#, Duan W#, Chen L#, Chen J#, Xu W, Fan Q, Li S, Liu Y, Wang S, He Q, Li X, Huang Y, Peng H, Zhao J, Zhang Q, Qiu Z, Shao Z, Zhang B, Wang Y, Tian Y*, Shu Y*, Qin Z*, Chi Y*. Potassium Ion Channel Modulation at Cancer-Neural Interface Enhances Neuronal Excitability in Epileptogenic Glioblastoma Multiforme. Neuron, 2025
Zhao J#, Zeng R#, Li X, Lu Y, Wang Z, Peng H, Chen H, Fu M, Zhang Y, Huang Y, Chen W, Wang X, Guan Y, Han W, Huang R, Yao C, Qin Z, Chen L, Chen L, Feng X, Yang H, Pereira P.M.R, Tong X, Li B, Zhang Q*, Chi Y*. Dura immunity configures leptomeningeal metastasis immunosuppression for cerebrospinal fluid barrier invasion. Nature Cancer, 2024
Fu M#, Zhao J#, Zhang L, Sheng Z, Li X, Qiu F, Feng Y, You M, Xu H, Zhang J, Zeng R, Huang Y, Li C, Chen W, Chen Z, Peng H, Li L, Wu Y, Ye D, Chi Y *, Hua W*, Mao Y*. Overcoming Tyrosine Kinase Inhibitor Resistance in Lung Cancer Brain Metastasis with CTLA4 Blockade. Cancer Cell, 2024
Pan L#, Peng H#, Lee B, Zhao J, Shen X, Yan X, Hua Y, Kim J, Kim D, Lin M, Zhang S, Li X, Yi X, Yao F, Qin Z, Du J, Chi Y*, Nam J*, Hyeon T*, Liu J *. Cascade Catalytic Nanoparticles Selectively Alkalize Cancerous Lysosomes to Suppress Cancer Progression and Metastasis. Advanced Materials, 2024
Peng H, Yao F, Zhao J, Zhang W, Chen L, Wang X, Peng Yang*, Tang J*, Chi Y*. Unravelling Mitochondria-Targeting ROS Modulation and their Implementations in Cancer Therapy by Nanomaterials. Exploration, 2023
Chi Y, Remsik J, Kiseliovas V, Derderian C, Sener U, Alghadir M, Saadeh F, Bale T, Pe’er D, Mazutis L and Boire A. Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis. Science.2020
Address: Floor 2, Building B, Medical Research Building, 131 Dong'an Road, Xuhui District, Shanghai
Postcode: 200032
Email: chiy@fudan.edu.cn
Address:No.138, medical college road 
Postcode:200032 
Tel/Fax:021-54237056
Emial:itbr@fudan.edu.cn220 Handan Rd., Shanghai(200433) Operator：+86-21-65642222 © 2019 FUDAN UNIVERSITY.
