Coherent Raman Scattering Microscope: label-free optical imaging
Background noise is the main limiting factor for CARS applications. Two picosecond light pulses with different center wavelengths are used as two Stokes, and they both interact with the pump and two images are obtained. The two sets of images are subtracted to suppress background noise. Although dual-wavelength picosecond lasers based on optical parametric oscillators (OPO) already exist, they are extremely expensive and require Titanium-sapphire (Ti:S) lasers and OPO. In addition, the optical delay lines are used to adjust the time interval between pump and Stokes.
Related publications：
1. B. Li, K. Charan, K. Wang, T. Rojo, D. Sinefeld, and C. Xu, “Nonresonant background suppression for coherent anti-Stokes Raman scattering microscopy using a multi-wavelength time-lens source,” Optics Express, vol. 24, pp. 26687-26695, 2016.
2. Y. Qin, B. Li, F. Xia, Y. Xia and C. Xu, “Multi-color background-free coherent anti-Stokes Raman scattering microscopy using a time-lens source,” Optics Express, vol. 26, pp. 34474-34483, 2018.
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