Nonlinear fiber optics: new femtosecond laser
Brain imaging relies on laser scanning microscope technology, and the development of laser scanning microscope technology requires a corresponding femtosecond laser. At present, the bottleneck of femtosecond lasers is (1) the center wavelength of most lasers is limited by the gain medium, which leads to the limited wavelength range, so they can only be applied to specific microscopes. (2) single-photon, two-photon, three-photon excitation requires different center wavelengths. However, many center wavelengths are still blank, and there is no corresponding femtosecond laser. The femtosecond laser developed by us can achieve continuous adjustment of the center wavelength between 800-1250 nm and 1600-2500 nm, which breaks through the original bottleneck and enriches the range of wavelength and multi-modal imaging of fluorescence microscopes.
Related publications：
1. B. Li, M. Wang, K. Charan, and C. Xu, “Investigation of the long wavelength limit of soliton self-frequency shift in a silica fiber,” Optics Express, vol. 26, pp. 19637-19647, 2018.
2. K. Charan, B. Li, M. Wang, C. P. Lin and C. Xu, “Fiber-based tunable repetition rate source for deep tissue two-photon fluorescence microscopy,” Biomedical Optics Express, vol. 9, pp. 2304-2311, 2018.
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