Chao Tan-INSTITUTE FOR TRANSLATIONAL BRAIN RESEARCH

Chao Tan

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Chao Tan Principal Investigator

Neurotransmission and brain diseases

Dr. Tan is a principal investigator at Institute for Translational Brain Research (ITBR) at Fudan University. Chao graduated from Zhejiang University and got his bachelor's degree in 2013. He received his Ph.D. in Medicine from Zhejiang University in 2018. In 2018, Chao joined Prof. Pascal S. Kaeser's laboratory at Harvard Medical School where he worked as a postdoc. He joined ITBR as an independent research group leader in 2023. His group focuses on clarifying the mechanisms underlying neurotransmission and brain diseases. He has authored 13 publications on peer-reviewed academic journals including Neuron, eLife, Cerebral Cortex, the Journal of Neuroscience, Stem Cell Reports, Cell Research etc. He also served as a reviewer for academic journals including Cellular and Molecular Neurobiology, International Immunopharmacology, Journal of Molecular Cell Biology and Neural Regeneration Research etc.

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Synaptic transmission is the basis for neuronal communications and normal functions in the brain. Clarifying the mechanisms underlying neurotransmission will help us understand how the brain works and how brain diseases happen. Our lab dissects the mechanisms for neurotransmission and neurodegenerative diseases using multiple techniques including mouse genetics, primary neuronal culture, electrophysiology, super-resolution microscopy, electron microscopy, mouse behavior etc. Our recent research interests include：(1) uncovering the mechanisms for synapse formation and synaptic transmission; (2) dissecting the neurotransmission abnormalities in brain diseases; (3) designing artificial molecules to improve synaptic transmission under the conditions of brain diseases.