Synapse formation and synaptic transmission is the basis for neuronal communications and normal functions in the brain. Clarifying the mechanisms underlying neurotransmission will help us understand how the brain works and how neurodegenerative diseases happen. Our lab dissects the mechanisms for neurotransmission and neurodegenerative diseases using multiple techniques including mouse genetics, primary neuronal culture, electrophysiology, super-resolution microscopy, electron microscopy, mouse behavior etc. Our recent research interests include：
(1) uncovering the mechanisms for synapse formation and synaptic transmission;
(2) dissecting the neurotransmission abnormalities in neurodegenerative diseases;
(3) designing artificial molecules to improve synaptic transmission under the conditions of neurodegenerative diseases.
Chao Tan, Shan Shan H. Wang, Giovanni de Nola, Pascal S. Kaeser. Rebuilding essential active zone functions within a synapse, Neuron, 2022, 110(9): 1498-1515.
Chao Tan, Giovanni de Nola, Claire Qiao, Cordelia Imig, Richard T. Born, Nils Brose, Pascal S. Kaeser. Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones, eLife, 2022, 11: e79077.
Chao Tan*, Nan-Nan Lu*, Cheng-Kun Wang, Dan-Yang Chen, Ning-He Sun, Hang Lyu, Jakob Körbelin, Wei-Xing Shi, Kohji Fukunaga, Ying-Mei Lu, Feng Han. Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4, Neuron, 2019, 101(5): 920-937.
Nan-Nan Lu*, Chao Tan*, Ning-He Sun, Ling-Xiao Shao, Xiu-Xiu Liu, Yin-Ping Gao, Rong-Rong Tao, Quan Jiang, Cheng-Kun Wang, Ji-Yun Huang, Kui Zhao, Guang-Fa Wang, Zhi-Rong Liu, Kohji Fukunaga, Ying-Mei Lu, Feng Han. Cholinergic Grb2-Associated-Binding Protein 1 Regulates Cognitive Function, Cerebral Cortex, 2018, 28(7): 2391-2404.
Shishi Li*, Huaye Pan*, Chao Tan*, Yaping Sun, Yanrui Song, Xuan Zhang, Wei Yang, Xuexiang Wang, Dan Li; Yu Dai, Qiang Ma, Chenming Xu, Xufen Zhu, Lijun Kang, Yong Fu, Xuejun Xu, Jing Shu, Naiming Zhou, Feng Han, Dajiang Qin, Wendong Huang, Zhong Liu, Qingfeng Yan. Mitochondrial Dysfunctions Contribute to Hypertrophic Cardiomyopathy in Patient iPSC-Derived Cardiomyocytes with MT-RNR2 Mutation, Stem Cell Reports, 2018, 10(3): 808-821.
Xing-Guang Liang, Chao Tan, Cheng-Kun Wang, Rong-Rong Tao, Yu-Jie Huang, Kui-Fen Ma, Kohji Fukunaga, Ming-Zhu Huang, Feng Han. Myt1l induced direct reprogramming of pericytes into cholinergic neurons, CNS Neuroscience & Therapeutics, 2018, 24(9): 801-809.
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