The brain, a marvelously complex organ, presents a myriad of challenges when it comes to investigating and treating brain diseases. To comprehend how a healthy brain operates and what goes wrong in brain disorders, it is crucial to provide a complete depiction of the intricate network of molecules and biochemical processes that span diverse brain regions and varying time periods. Molecular imaging, a well-established technique in biological research, stands as a valuable tool for uncovering the mysteries of the brain. To advance brain research, gain a deeper understanding of neurological disorders, and develop effective therapies, the Su Lab is focused on creating innovative ways to use molecular imaging in brain disease research. These efforts include:
Pioneering generalizable bioluminescent biosensor designs for brain disease research
Advancing multiplex imaging for brain research by innovating protein reporter systems
Advancing brain disease drug development through optical protein biosensors
Illuminating neurological disorders by probing abnormal protein behaviors with optical biosensors
Wu, Y.*, Walker, J. R., Ning, L., Westberg, M., Monje, M., Kirkland, T. A., Lin, M. Z.#, Su, Y.*#, Kinase-modulated bioluminescent indicators enable noninvasive imaging of drug activity in the brain ACS Cent. Sci. (2023) 9(4), 719-732
Su, Y.*, Walker, J. R.*, Hall, M. P., Klein, M. A., Wu, X., Encell, L. P., Casey, K. M., Liu, L. X., Hong, G., Lin, M. Z. and Kirkland, T. A., An optimized bioluminescent substrate for non-invasive imaging in the brain. Nat. Chem. Biol., (2023) 19, 731-739.
Su, Y.*, Walker, J. R.*, Park, Y., Smith, T. P., Liu, L. X., Hall, M. P., Labanieh, L., Hurst, R., Wang, D. C., Encell, L. P., Kim, N., Zhang, F., Kay, M. A., Casey, M. K., Majzner, R. G., Cochran. J. R., Mackall, C. L., Kirkland, T. A., Lin, M. Z., Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals, Nat. Methods, (2020) 17, 852-860.
Bose, D.*, Su, Y.*, Marcus, A., Raulet, D. H., Hammond, M. C., An RNA-based fluorescent biosensor for high-throughput analysis of cGAS-cGAMP-STING pathway Cell. Chem. Biol., (2016) 23, 1539-1549.
Su, Y., Hickey, S. F., Keyser, S. G. L., Hammond, M. C., In vitro and in vivo enzyme activity screening via RNA-based fluorescent biosensors for S-adenosyl-L-homocysteine (SAH) J. Am. Chem. Soc. (2016) 138, 7040-7047.
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