Email:zhang_ran@fudan.edu.cn
Research Direction:Ion channel gating and neurotransmitter transmission mechanisms
Education:
Ph.D. in Biology, Tsinghua University, Aug 2013 – Jul 2020
B.Sc. in Biology, Sichuan University, Sep 2009 – Jul 2013
Work experience:
2020.12 - 2022.12 Tsinghua University Postdoctor Structural Biology
Publications:
1. Xiangyun Fang#, Haichao Jin#, Jin Wang*, Ran Zhang*, Baobin Li* (2025). Structural Insights into the Gating Mechanism of the Two-Pore Domain Potassium Channel THIK1. Nature Structural and Molecular Biology (Accepted)
2. Qixian He#, Ran Zhang#, Sandrine Tury#, Valérie Courgnaud, Fenglian Liu, Jean-luc Battini*, Baobin Li* & Qingfeng Chen* (2025). Structural basis of phosphate export by human XPR1. Nat Commun 16, 683 (2025). https://doi.org/10.1038/s41467-025-55995-8.
3. Ruizhu Chen#, Ran Zhang#, Lu Li#, Bozhan Wang#, Zhiwei Gao, Fenglian Liu, Yan Chen, Yutao Tian *, Baobin Li*, and Qingfeng Chen* (2024). Structure basis for sugar specificity of gustatory receptors in insects. Cell Discovery. https://doi.org/10.1038/s41421-024-00716-6.
4. Xu G#, Zhang R#, Li H, Yin K, Ma X, Lou Z*. (2022) Structural basis for the neurotropic AAV9 and the engineered AAV-PHP.eB recognition with cellular receptors. Molecular Therapy – Methods & Clinical Development, 26, 52–60.
5. Zhang R#, Xu G#, Cao L#, Sun Z#, He Y, Cui M, Sun Y, Li S, Li H, Qin L, Hu M, Yuan Z, Rao Z, Ding W, Rao Z, Lou Z*. (2019) Divergent engagements between adeno-associated viruses and their cellular receptor AAVR. Nature Communications, 10(1): 3760.
6. Zhang R#, Cao L#, Cui M#, Sun Z, Hu M, Zhang R, Stuart W, Zhao X, Yang Z, Li X, Sun Y, Li S, Li H, Ding W*, Lou Z*, Rao Z. (2019) Adeno-associated virus 2 bound to its cellular receptor AAVR. Nature Microbiology, 4(4): 675–682.
7. Cao L#, Zhang R#, Liu T#, Sun Z#, Hu M, Sun Y, Cheng L, Guo Y, Fu S, Hu J, Li X, Yu C, Wang H, Chen H, Li X, Fry EE, Stuart DI, Qian P*, Lou Z*, Rao Z. (2018) Seneca Valley virus attachment and uncoating mediated by its receptor anthrax toxin receptor 1. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 115(51): 13087–13092.
Achievements
Postdoctoral Innovation Talents Support Program (2021)
“Shui-Mu Scholar” of Tsinghua University (2020)
Outstanding Graduate of Tsinghua University (2020)
Outstanding Doctoral Dissertation Award, Tsinghua University (2020)