Mechanism of Microglial Debris Clearance-INSTITUTE FOR TRANSLATIONAL BRAIN RESEARCH

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Mechanism of Microglial Debris Clearance

Date:2022-09-05 ClickTimes:

Microglial debris is cleared by astrocytes and Müller glia via a C4b-mediated pathway and degraded through a RUBICON-dependent non-canonical autophagy pathway.

Zhou T., Li Y., Li X., Zeng F., Rao Y., He Y., Wang Y., Liu M., Li D., Xu Z., Zhou X., Du S., Niu F., Peng J., Mei X., Ji S.-J., Shu Y., Lu W., Guo F., Wu T., Yuan T.-F., Mao Y. and Peng B.* (2022) Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent non-canonical autophagy. Nature Communications (in press).

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