Focusing on the general direction of "Memory Principles and Applications", relying on the advantages of the institute in intersectional, integrational, and translational brain research(ITBR), we are committed to promoting the innovative application of modern molecular biology, Advanced Microscopy, cell biology and other related technologies in memory research with an emphasis on the memory types such as emotional memory, feeding memory, and motor memory. We have been long engaged in analyzing the basic features of memory engrams and their neurobiological basis from multiple dimensions, portraying the physiological nature of normal life activities such as emotion, nutritional metabolism, motor behaviors and their impairments, with the goal of reconstruction and synthesis. Meanwhile, we are also going to expand the application of memory principles in brain-body interaction regulation to understand the symptom evolution and functional rehabilitation in chronic diseases. We hope to develop new methods and modalities of peripheral and central stimulation that are capable of evoking persistent changes in brain activity equivalent to "memory", and then to address the evolutionary process and molecular driving forces of characteristic cell ensembles with a markedly pro-rehabilitation effect in the brain, and ultimately to establish new strategies of disease intervention based on memory principles for clinical translation and application.