Discovery of de nevo cell reprogramming factor BRD3R
Due to the long reprogramming time and low efficiency of iPSC, we speculated exsistence of "Roadblocker" or other undiscovered somatic cell reprogramming promoting factors. Through a large amount of genetic screening, we successfully discovered a new somatic cell reprogramming factor BRD3R.Further sequencing and comparison showed that BRD3R belongs to the BET family and acts as an epigenetic recognition factor to recognize acetylated histones. We also found that BRD3R can not only improve the reprogramming efficiency of human skin fibroblasts, but accelerate the formation of iPSCs. Through transcriptomics analysis, we discoved that BRD3R prompted the formation of iPSCs by reset of the cell cycle of pluripotent stem cells via upregulating 128 mitotic-related genes. In conclusion, this research discovered a new epigenetic factor that promotes the formation of iPSCs.
The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis.Nature Communications2016,7, 10869.
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