Shumin Duan-INSTITUTE FOR TRANSLATIONAL BRAIN RESEARCH

Shumin Duan

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Shumin Duan Member of the Chinese Academy of Sciences

Neural Circuit Analysis of Brain Function

Shumin Duan received his Ph.D. from Kyushu University in Japan in 1991 and postdoctoral training at the University of Hawaii and the University of California at San Francisco from 1997-1999. His research interests cover several important topics in neuroscience, including 1) the function and the mechanisms of neuron-glia interactions in health and disease; 2) the development, function, and plasticity of synapses; and 3) neural circuits basis of innate behaviors (including sleep and waking, emotion, and aggressive behaviors) and their related disease.

Dr Duan is an academician of the Chinese Academy of Sciences and a member of the Academy of Sciences for the Developing World (TWAS). He served as the president of the Chinese Society for Neuroscience from 2011 to 2019. He is currently the Editor-in-Chief of Neuroscience Bulletin (an official journal of the Chinese Society for Neuroscience), the Advisory Board member of Neuron, and an editorial board member in several international neuroscience journals.

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Engaged in neuroscience research for many years, Shumin Duan has made systematic innovations in neuron-glial cell interaction, synaptic development and function, and neural circuit analysis for precise regulation of brain function.

Research directions include:

1. The regulation mechanism of ATP released by glial cells on synaptic plasticity;

2. The transport and release mechanism of neuronal presynaptic vesicles;

3. The transport and release mechanism of microglia vesicles;

4. Early neuronal network formation;

5. The neural circuit basis of mood and mood-related diseases.

The research methods mainly include:

1. Single and double patch clamp recordings in cultured neurons and isolated brain slices;

2. Morphological studies of confocal and electron imaging;

3. Live-cell time-lapse imaging, combined with protein transfection with GFP for the study of the dynamic distribution of some important protein molecules, organelle movement and vesicle secretion;

4. Using transgenic animals and conditional gene knockout mice produced by the use of glial cell specific molecules as promoters and the Cre-LoxP system to interfere with the specific molecules in the glia for investigating the roles of glial cells in various neurological functions;

5. Combined optogenetics, animal behavior with virus reverse tracking to study the roles of specific types of neurons in emotion or disease-related neural circuits.