The research titled "Glia instruct axon regeneration via a ternary modulation of neuronal calcium channels in Drosophila" was published in "Nature Communications" on October 14, 2023. This study reveals that glia play a crucial role in dictating axon regeneration specificity through a three-layered and balanced modulation of neuronal calcium channels. We discovered that in Drosophila sensory neurons, specifically the regenerative Class IV da (C4da) neurons, axotomy-induced Ca2+ transients are essential for regeneration. These transients are mediated by L-type calcium channels, forming the core intrinsic machinery. In contrast, Class III da (C3da) neurons, which fail to regenerate, do not exhibit these significant Ca2+ transients after injury. This intricate system highlights how glia actively shape neuronal regenerative capacity, not only by promoting it through TNF and Irk1 signaling but also by providing inhibitory signals like adenosine to fine-tune the process. The findings suggest that manipulating this multifaceted glia-neuron coupling could be a promising avenue for promoting neural repair.
https://www.nature.com/articles/s41467-023-42306-2
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