The research titled "The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation" was published in "Nature Communications" on June 22, 2021. This study reveals that the Atr-Chek1 pathway, traditionally known for its role in the DNA damage response, also functions as a negative regulator of axon regeneration in neurons. We discovered that in Drosophila sensory neurons, inhibiting Atr or Chek1, or overexpressing Cdc25, promotes axon regeneration, whereas overexpression of Atr or Chek1, or knockdown of Cdc25, impedes regeneration. This inhibition is mediated by the mechanosensitive ion channel Piezo and its downstream NO signaling, independent of DNA damage. The study highlights the Piezo-Atr-Chek1-Cdc25 axis as an evolutionarily conserved mechanism that suppresses axon regeneration and identifies potential therapeutic targets for treating nervous system trauma.
https://www.nature.com/articles/s41467-021-24131-7
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