The research titled "Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System" was published in "Cell Metabolism" on November 3, 2020. Through a combination of genetic manipulation and metabolic analysis, it revealed that reprogramming glial cells to enhance glycolysis can significantly promote axon regeneration and functional recovery in the central nervous system (CNS). Study identified specific metabolic pathways in glial cells that can be harnessed to overcome the inhibitory environment typically found in the CNS after injury. We discovered that increasing the levels of metabolites such as L-lactate and L-2-hydroxyglutarate (L-2HG) in glial cells can boost axon regeneration by acting on neuronal GABAB receptors. This finding not only provides a novel mechanism for promoting CNS repair but also highlights the potential therapeutic applications of targeting glial metabolism for treating neurotrauma and neurodegenerative diseases.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30475-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413120304757%3Fshowall%3Dtrue
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