E-mail: xjguo20(AT)fudan
Research Direction: Metabolic and endocytic mechanisms underlying tumour targeted therapy
Biography
Education
2020.06 – 2025.06: PhD in Surgery, Department of Hepatobiliary Surgery and Liver Transplantation, Fudan University
2015.09 – 2020.06: Bachelor of Medicine, Fudan University
Publications
(1) Liang C#, Ye M#, Yu L#, Zhang PF#, Guo XJ#, Meng XL, Zeng HY, Hu SY, Zhang DH, Sun QM, Shen YH, Cai JB, Li SQ, Chen Z, Shi YH, Ke AW, Shi YG, Zhou J, Fan J, Wu FZ, Huang XY, Shi GM, Tang Z, Lu JC. Lysine-specific demethylase 1 deletion reshapes tumour microenvironment to overcome acquired resistance to anti-programmed death 1 therapy in liver cancer. Clin Transl Med. 2025 May;15(5):e70335.
(2) Guo X#, Huang X#, Yang X#, Lu J#, Wei C#, Gao C, Pei Y, Chen Y, Sun Q, Cai JB, Zhou J, Fan J, Ke AW, Shi Y*, Shen Y*, Zhang P*, Shi G*, Yang G*. Loss of 5-hydroxymethylcytosine induces chemotherapy resistance in hepatocellular carcinoma via the 5-hmC/PCAF/AKT axis. Cell Death Dis. 2023 Feb 2;14(2):79.
(3) Lu J#, Zhang P#, Huang X#, Guo X#, Gao C, Zeng H, Zheng Y, Wang S, Cai J, Sun Q, Shi Y, Zhou J, Ke A*, Shi G*, Fan J*. Amplification of spatially isolated adenosine pathway by tumor-macrophage interaction induces anti-PD1 resistance in hepatocellular carcinoma. J Hematol Oncol. 2021 Nov 27;14(1):200.
(4) Guo X#, Lu J#, Zeng H#, Zhou R#, Sun Q#, Yang G, Pei Y, Meng X, Shen Y, Zhang P, Cai J, Huang P, Ke A, Shi Y, Zhou J, Fan J, Chen Y*, Yang L*, Shi G*, Huang X*. CTLA-4 Synergizes With PD1/PD-L1 in the Inhibitory Tumor Microenvironment of Intrahepatic Cholangiocarcinoma. Front Immunol. 2021 Aug 30;12:705378.
Awards & Honors：
National Scholarship（2021）
Address:No.138, medical college road 
Postcode:200032 
Tel/Fax:021-54237056
Emial:itbr@fudan.edu.cn