Intracellular calcium ion homeostasis is essential for maintaining physiological processes in the body. Trimeric Intracellular Cation (TRIC) channels are a novel class of ion channels localized within the intracellular membrane system, which respond to and regulate the CICR (Calcium-Induced Calcium Release) process within the intracellular calcium signaling network. This study was the first internationally to reveal the unique ion selectivity pathway, gating properties, and calcium-responsive regulatory mechanisms of TRIC channels. It expands our understanding of the structural basis and regulatory mechanisms of intracellular cation channels and advances insights into the interactions between intracellular ion channels and the signaling lipid PIP₂. These findings provide a new perspective for physiological and pharmacological studies on calcium signaling regulation in neuronal cells (Nature, 2016).
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