Enteric ATF4 regulates stress-related behaviors via gut-brain axis
Abstract
Stress and depression is related to intestinal dysfunction. However, the contribution of the intestinal signals to stress-induced behavioral alterations and its mechanisms are poorly understood. Here we found gut epithelial activating transcription factor 4 (ATF4) plays an important role in stress-related behaviors. In mice, intestinal ATF4 deficiency led to reduced peptide trefoil factor 3 levels, which activated paraventricular thalamic glutamatergic neurons to influence stress-related behaviors. These findings highlight the importance of gut signals to the stress-related behavioral alterations and provide possible therapeutic strategies for stress-related behavioral symptoms.
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