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Tao Wang Principal Investigator
Neurodegenerative diseases and metabolic regulation

The metabolic decline is one of the most common features of aging, and it is closely involved in developing multiple neurodegenerative diseases (NDDs), including ALS and FTD. Genetic mutation-associated or aging-associated metabolic decline can be a powerful mechanism to trigger defective signal transductions, intracellular stress build-up, and protein homeostasis collapse, ultimately leading to neuronal cell death in ALS/FTD. We will leverage multiple model systems to identify how the metabolic decline is induced in the process of ALS/FTD and through which pathways the metabolic decline triggers the molecular cascades of neuronal death.

Our recent research interests include：

1. Uncovering the underlying mechanisms and critical regulators for mitochondrial dysregulation and metabolic disturbance in ALS/FTD.

2. Elucidating the interplay between metabolic disturbance and pathological alternations during the development of NDDs.

The metabolic decline is one of the most common features of aging, and it is closely involved in developing multiple neurodegenerative diseases (NDDs), including ALS and FTD. Genetic mutation-associated or aging-associated metabolic decline can be a powerful mechanism to trigger defective signal transductions, intracellular stress build-up, and protein homeostasis collapse, ultimately leading to neuronal cell death in ALS/FTD. We will leverage multiple model systems to identify how the metabolic decline is induced in the process of ALS/FTD and through which pathways the metabolic decline triggers the molecular cascades of neuronal death.

Our recent research interests include：

1. Uncovering the underlying mechanisms and critical regulators for mitochondrial dysregulation and metabolic disturbance in ALS/FTD.

2. Elucidating the interplay between metabolic disturbance and pathological alternations during the development of NDDs.

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