This study, titled "BLA DBS ameliorates anxiety and fear by restoring weakened synaptic transmission from the basolateral amygdala (BLA) to the anterior dorsal bed nucleus of the stria terminalis (adBNST) and central lateral amygdala (CeL) in a foot shock mouse model of PTSD," was published online in Cell Reports in August 2024. The principal findings demonstrate that BLA deep brain stimulation (DBS) rectifies diminished synaptic transmission within BLA-adBNST and BLA-CeL circuits in a PTSD rodent model, thereby alleviating anxiety- and fear-like behaviors in foot shock (FS) mice. The research elucidates the circuit-level mechanisms underlying BLA-DBS-mediated PTSD symptom improvement and elucidates the neurobiological role of altered BLA excitatory synaptic transmission in the pathogenesis of PTSD-associated fear and anxiety. These findings provide critical insights into the neural circuit dysregulation of PTSD and the therapeutic action of BLA-DBS, while establishing a foundational theoretical framework for developing precision-targeted neuromodulation strategies to treat PTSD patients.
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