This study, titled "STN–ANT plasticity is crucial for motor control in Parkinson’s disease models," was published online in Signal Transduction and Targeted Therapy in June 2021. The findings reveal that synaptic plasticity within the STN-ANT (subthalamic nucleus-anterior thalamic nucleus) circuit modulates motor behaviors in rodent models of Parkinson’s disease (PD). This newly identified STN-ANT pathway potentially transmits motor signals from the basal ganglia STN to the cingulate cortex, integrates sensory-motor information through synaptic plasticity, and thereby contributes to the regulation of PD-associated motor deficits.
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