The Clearance Mechanism of Microglial Debris-INSTITUTE FOR TRANSLATIONAL BRAIN RESEARCH

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The Clearance Mechanism of Microglial Debris

Date:2022-09-05 ClickTimes:

Microglial debris is cleared by astrocytes and Müller glia via a C4b-mediated pathway and degraded through a non-canonical autophagy pathway dependent on RUBICON.

Zhou T., Li Y., Li X., Zeng F., Rao Y., He Y., Wang Y., Liu M., Li D., Xu Z., Zhou X., Du S., Niu F., Peng J., Mei X., Ji S.-J., Shu Y., Lu W., Guo F., Wu T., Yuan T.-F., Mao Y. and Peng B.* (2022) Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent non-canonical autophagy. Nature Communications (in press).

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