Unlike conventional synapses, autapses are self-synapses providing feedback regulation of a neuron’s own activity. We find that autapses selectively form in a subpopulation of subicular PCs, but are entirely absent in other HPF PCs, suggesting a key role of autapses in regulating the self-activity of individual subicular PCs and thereby the primary output of HPF. Additionally, autapses of subicular PCs emerge earlier than those in mPFC, and their time course correlates well with developmental changes in neuronal morphology. Therefore, the selective and early formation of autapses in subicular PCs may play a vital role in early-life cognitive functions. Pan et al., 2025.
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