主要研究方向为CRISPR为基础的新型基因编辑工具的开发及优化，并针对神经系统疾病开展基因治疗研究以推动基因编辑技术的临床转化。课题组主要运用分子生物学、细胞生物学、高通量筛选、流式细胞分选、RNA-Seq和单细胞测序等多种手段开展原创性的基因编辑技术研发工作。
邮箱：jordan_marley@qq.com
研究方向：单碱基基因编辑工具的优化及自闭症易感基因的功能研究
邮箱：22111520006@m.fudan.edu.cn
研究方向：基因编辑工具的开发、优化及应用
邮箱：22211520017@m.fudan.edu.cn
研究方向：基因编辑工具的开发、优化及应用
邮箱：fudanczhang@163.com
研究方向：基因编辑工具CRISPR开发与优化，及其在神经系统疾病中的应用
邮箱：zhang.shuqian@163.com
研究方向：新型基因编辑工具的开发及神经系统疾病的基因治疗
Zhang, S., Song, L., Yuan, B., Zhang, C., Cao, J., Chen, J., Qiu, J., Tai, Y., Chen, J., Qiu, Z., Zhao, X. M., & Cheng, T. L. (2023). TadA reprogramming to generate potent miniature base editors with high precision. Nature communications, 14(1), 413
Zhang, S., Yuan, B., Cao, J., Song, L., Chen, J., Qiu, J., Qiu, Z., Zhao, X. M., Chen, J., & Cheng, T. L. (2023). TadA orthologs enable both cytosine and adenine editing of base editors. Nature communications, 14(1), 414.
Li Shuo, Bo Yuan, Jixin Cao, Jingqi Chen, Jinlong Chen, Jiayi Qiu, Xing-Ming Zhao, Xiaolin Wang*, Zilong Qiu*, Tian-Lin Cheng* (2020). Docking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination, Nature Communications, 11:5827.
Tian-Lin Cheng*, Shuo Li, Bo Yuan, Xiaolin Wang, Wenhao Zhou, Zilong Qiu* (2019). Expanding C-T base editing toolkit with diversified cytidine deaminases, Nature Communications, 10:3612
Yuan Cai#,Tianlin Cheng#,Yichuan Yao#, Xiao Li, Yuqian Ma, Lingyun Li, Huan Zhao, Jin Bao, Mei Zhang*, Zilong Qiu*, Tian Xue*(2019). In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway, Science Advances, eaav3335
Tian-Lin Cheng*, Zilong Qiu*(2019). Long non-coding RNA tagging and expression manipulation via CRISPR/Cas9-mediated targeted insertion, Protein Cell, 9: 820
Ling-jie He#, Nan Liu#, Tian-lin Cheng, Xiao-jing Chen, Yi-ding Li, Yousheng Shu, Zilong Qiu, and Xiaohui Zhang(2014). Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in absence of critical period plasticity, Nature communications, 5:5036
Tian-Lin Cheng, Zhizhi Wang, Qiuming Liao, Ying Zhu, Wen-Hao Zhou, Wenqing Xu, Zilong Qiu*(2014). MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex, Developmental Cell, 28:547-560
地址: 上海市徐汇区医学院路138号科研2号楼二楼
邮编: 200032
电话/传真: 021-54237827
邮箱: chengtianlin@fudan.edu.cn
地址：上海市徐汇区医学院路138号 
邮编：200032 
电话/传真：021-54237056 
邮箱：itbr@fudan.edu.cn 地址：上海市徐汇区医学院路138号，邮编：200032，电话：54237056，复旦大学脑科学转化研究院 版权所有
