李澄 博士后

日期:2024-04-03 点击数: 来源:

邮箱:19111010056@fudan.edu.cn

研究方向:中枢神经系统药物递送,抗体药物机制研究


教育经历

2019-2024 复旦大学基础医学院  博士

2015-2019 复旦大学药学院 本科


代表性研究成果

1. Cheng Li, Zhenlin Yang*, Yanling Wu*, Tianlei Ying*. Evaluation of vaccine effectiveness against SARS‐CoV‐2 variants by serological epitope profiling. Clinical and Translational Medicine. 2023 Jan; 13(1): e1182

2.  Cheng Li#, Wuqiang Zhan#, Zhenlin Yang#, Chao Tu#, Gaowei Hu#, Xiang Zhang, Wenping Song, Shujuan Du, Yuanfei Zhu, Keke Huang, Yu Kong, Meng Zhang, Qiyu Mao, Xiaodan Gu, Yi Zhang, Youhua Xie, Qiang Deng, Yuanlin Song, Zhenguo Chen, Lu Lu, Shibo Jiang, Yanling Wu*, Lei Sun*, Tianlei Ying*. Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody. Cell. 2022 Apr 14;185(8):1389-1401.e18.

3.   Cheng Li#, Xiaolong Tian# , Xiaodong Jia# , Jinkai Wan, Lu Lu, Shibo Jiang, Fei Lan, Yinying Lu*, Yanling Wu*, Tianlei Ying*. The impact of receptor-binding domain natural mutations on antibody recognition of SARS-CoV-2. Signal Transduct Target Ther 2021 Mar 23;6(1):132.

4.  Cheng Li, Tianlei Ying*, Dimiter S Dimitrov*, Yanling Wu*. Counter changes with changelessness: Cope with SARS-CoV-2 immune evasion by targeting cryptic epitopes. Life Medicine. 2022 August; 1(1):24-26.

5.   Yanling Wu, Cheng Li, Shuai Xia, Xiaolong Tian, Yu Kong, Zhi Wang, Chenjian Gu, Rong Zhang, Chao Tu, Youhua Xie, Zhenlin Yang, Lu Lu, Shibo Jiang, Tianlei Ying. Identification of Human Single-Domain Antibodies against SARS-CoV-2. Cell Host Microbe. 2020 Jun 10;27(6):891-898.e5.

6. Aihua Hao#Wenping Song#, Cheng Li#, Xiang Zhang, Chao Tu, Xun Wang, Pengfei Wang, Yanling Wu*, Tianlei Ying*, Lei Sun*. Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants. Signal Transduction and Targeted Therapy. 2023 Jul 8;8(1):269.

7.   Farong Ye#, Cheng Li#, Feng-Liang Liu#, Xinliang Liu, Peng Xu, Rong-Hua Luo, Wenping Song, Yong-Tang Zheng, Tianlei Ying*, Biao Yu*, Ping Wang*. Semisynthesis of homogeneous spike RBD glycoforms from SARS-CoV-2 for profiling the correlations between glycan composition and function. National Science Review. 2024 Jan 22;11(2):nwae030.

8. Xiaolong Tian#, Cheng Li#, Ailing Huang, Shuai Xia, Sicong Lu, Zhengli Shi, Lu Lu, Shibo Jiang, Zhenlin Yang*, Yanling Wu*, Tianlei Ying*. Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody. Emerging Microbes & Infectious. 2020 Feb 17;9(1):382-385.

9.  Xiaolong Tian, Cheng Li, Yanling Wu*, Tianlei Ying*. Deep Mining of Human Antibody Repertoires: Concepts, Methodologies, and Applications. Small Methods.2020 Sep 4(10):2000451

10. Wenjing Tang#, Zui Zhang#, Cheng Li#, Yuxiu Chu, Jun Qian, Tianlei Ying*, Weiyue Lu*, Changyou Zhan*. Facile Separation of PEGylated Liposomes Enabled by Anti-PEG scFv. Nano Letters. 2021 Dec 8;21(23):10107-10113.

11.  Zui Zhang#, Yuxiu Chu#, Cheng Li#, Wenjing Tang, Jun Qian, Xiaoli Wei, Weiyue Lu, Tianlei Ying*, Changyou Zhan*. Anti-PEG scFv corona ameliorates accelerated blood clearance phenomenon of PEGylated nanomedicines. Journal of Controlled Release. 2021 Feb 10:330:493-501.

12.  Xiaolong Tian#, Cheng Li#, Yanling Wu*, Tianlei Ying*. Insights into biological therapeutic strategies for COVID-19. 2021 Mar 1(2):166-178


学术奖励

1. 相辉奖学金, 2019

2一健康基金新生奖, 2021

3. 硕士国家奖学金,2020

4. 博士国家奖学金,2021

5. 博士国家奖学金,2022

6. “一健康基金优秀研究生,2021

8. 复旦大学第13届学术之星特等奖,2022

9. 复旦大学优秀学生,2022

7. CSBMB中国生物化学与分子生物学会2023年度罗氏大学研究基金入围奖2023

10.复旦大学博士生学术论坛基础医学院论坛一等奖2023



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