原飞翔青年副研究员-复旦大学脑科学转化研究院

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原飞翔青年副研究员

日期：2022-02-15 点击数：来源：

邮箱：feixiangyuan@fudan.edu.cn

研究方向：主要研究方向为代谢稳态的中枢调控机制

经历简介：

教育经历：

2010-2014 中国海洋大学食品科学与工程学院, 工学学士

2014-2019 中国科学院大学上海生命科学研究院, 理学博士

工作经历：

2019- 2022 中国科学院营养与健康研究所，博士后

2022年加入复旦大学脑科学与转化研究院，青年副研究员

学术奖励：

中国博士后科学基金特别资助 (2021年)

国家自然科学基金青年科学基金 (2021年)

中国博士后科学基金面上资助 (2020年)

代表性论文：

1.YuanFeixiang^#, ZhouZiheng^#, Wu Shangming, Jiao Fuxin, Chen Liang, Fang Leilei, YinHanrui, Hu Xiaoming, Jiang Xiaoxue, Liu Kan, Xiao Fei, Jiang Haizhou, Chen Shanghai, LiuZhanju, Shu Yousheng andGuoFeifan*.Intestinal activating transcription factor 4 regulates stress-related behavioral alterations via paraventricular thalamus in male mice.PNAS. 2023 (accepted)

2.Yuan Feixiang^#, Wu Shangming^#, Zhou Ziheng^#, Jiao Fuxin, Yin Hanrui, Niu Yuguo, Jiang Haizhou, Chen Shanghai, Guo Feifan*. Leucine deprivation results in antidepressant effects via GCN2 in AgRP neurons.Life Metabolism.2023 Advance access publication 4 February. doi.org/10.1093/lifemeta/load004

https://academic.oup.com/lifemeta/advance-article/doi/10.1093/lifemeta/load004/7026143?searchresult=1

3.Yin Hanrui,Yuan Feixiang, Jiao Fei, Niu Yuguo, Jiang Xiaoxue, Deng Jiali, Guo Yajie, Chen Shanghai, Zhai Qiwei, Hu Chen*, Li Yiming*, Guo Feifan*. Intermittent Leucine Deprivation Produces Long-lasting Improvement in Insulin Sensitivity by Increasing Hepatic Gcn2 Expression.Diabetes. 2022 Feb 1;71(2):206-218.

https://diabetesjournals.org/diabetes/article-abstract/71/2/206/138955/Intermittent-Leucine-Deprivation-Produces-Long?redirectedFrom=fulltext

4. Yuan Feixiang^#, Yin Hanrui^#, Deng Yalan, Jiao Fuxin, Jiang Haizhou, Niu Yuguo, Chen Shanghai, Ying Hao, Zhai Qiwei, Chen Yan, Guo Feifan*. Overexpression of Smad7 in hypothalamic POMC neurons disrupts glucose balance by attenuating central insulin signaling.Molecular Metabolism. 2020 Dec;42:101084.

https://www.sciencedirect.com/science /article/pii/S2212877820301587?via%3Dihub

5. Yuan Feixiang, Jiang Haizhou, Yin Hanrui, Jiang Xiaoxue, Jiao Fuxin, Chen Shanghai, Ying Hao, Chen Yan, Zhai Qiwei, Guo Feifan*. Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation.Nature Communications. 2020 Jun 5;11(1):2847.

https://www.nature.com/articles/s41467-020-16662-2

6.Deng Jiali, Guo Yajie,Yuan Feixiang, Chen Shanghai, Yin Hanrui, Jiang Xiaoxue, Jiao Fuxin, Wang Fenfen, Ji Hongbin, Hu Guohong, Ying Hao, Chen Yan, Zhai Qiwei, Xiao Fei*, Guo Feifan*. Autophagy inhibition prevents glucocorticoid-increased adiposity via suppressing BAT whitening.Autophagy. 2020 Mar;16(3):451-465.

https://www.tandfonline.com/doi/full/10.1080/15548627.2019.1628537

7.Hu Xiaoming, Deng Jiali, Yu Tianming, Chen Shanghai, Ge Yadong, Zhou Ziheng, Guo Yajie, Ying Hao, Zhai Qiwei, Chen Yan,Yuan Feixiang, Niu Yuguo, Shu Weigang, Chen Huimin, Ma Caiyun, Liu Zhanju*, Guo Feifan*. ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides.Gastroenterology. 2019 Mar;156(4):1098-1111.

https://www.gastrojournal.org/article/S0016-5085(18)35281-8/fulltext?referrer=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F

8.Deng Yalan, Xiao Yuzhong,Yuan Feixiang, Liu Yaping, Jiang Xiaoxue, Deng Jiali, Fejes-Toth Geza, Naray-Fejes-Toth Aniko, Chen Shanghai, Chen Yan, Ying Hao, Zhai Qiwei, Shu Yousheng, Guo Feifan*. SGK1/FOXO3 Signaling in Hypothalamic POMC Neurons Mediates Glucocorticoid-Increased Adiposity.Diabetes. 2018 Apr;67(4):569-580.

https://diabetesjournals.org/diabetes/article/67/4/569/39939/SGK1-FOXO3-Signaling-in-Hypothalamic-POMC-Neurons

9.Xiao Yuzhong, Deng Yalan,Yuan Feixiang, Xia Tingting, Liu Hao, Li Zhigang, Liu Zhixue, Ying Hao, Liu Yi, Zhai Qiwei, Chen Shanghai, Guo Feifan*. An ATF4-ATG5 signaling in hypothalamic POMC neurons regulates obesity.Autophagy. 2017 Jun 3;13(6):1088-1089.

https://www.tandfonline.com/doi/full/10.1080/15548627.2017.1307488

10.Xiao Yuzhong, Deng Yalan,Yuan Feixiang, Xia Tingting, Liu Hao, Li Zhigang, Liu Zhixue, Ying Hao, Liu Yi, Zhai Qiwei, Chen Shanghai, Guo Feifan*. ATF4/ATG5 Signaling in Hypothalamic Proopiomelanocortin Neurons Regulates Fat Mass via Affecting Energy Expenditure.Diabetes. 2017 May;66(5):1146-1158.

https://diabetesjournals.org/diabetes/article/66/5/1146/40698/ATF4-ATG5-Signaling-in-Hypothalamic

11.Deng Jiali^#,Yuan Feixiang^#, Guo Yajie, Xiao Yuzhong, Niu Yuguo, Deng Yalan, Han Xiao, Guan Youfei, Chen Shanghai, Guo Feifan*. Deletion of ATF4 in AgRP Neurons Promotes Fat Loss Mainly via Increasing Energy Expenditure.Diabetes. 2017 Mar;66(3):640-650.

https://diabetesjournals.org/diabetes/article/66/3/640/16645/Deletion-of-ATF4-in-AgRP-Neurons-Promotes-Fat-Loss

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