邮箱：xjguo20(AT)fudan.edu.cn
研究方向：肿瘤靶向治疗相关代谢及内吞机制
经历简介：
教育经历
2020.06-2025.06 复旦大学，外科学，博士
2015.09-2020.06 复旦大学，临床医学（五年制），学士
代表性论文:
(1) Liang C#, Ye M#, Yu L#, Zhang PF#, Guo XJ#, Meng XL, Zeng HY, Hu SY, Zhang DH, Sun QM, Shen YH, Cai JB, Li SQ, Chen Z, Shi YH, Ke AW, Shi YG, Zhou J, Fan J, Wu FZ, Huang XY, Shi GM, Tang Z, Lu JC. Lysine-specific demethylase 1 deletion reshapes tumour microenvironment to overcome acquired resistance to anti-programmed death 1 therapy in liver cancer. Clin Transl Med. 2025 May;15(5):e70335.
(2) Sun P#, Wang X#, Huang Y#, Zhang J, Shen X, Dong A, Wang S, Guo X, Shi G, Ding J*, Chi Y*, Yang H*. Substrate Coupling and Inhibition of the human Na⁺-dependent Cl⁻/HCO₃⁻ exchanger NCBE. bioRxiv 2025 (Nat. Commun. 2026, in press)
(3) Guo X#, Huang X#, Yang X#, Lu J#, Wei C#, Gao C, Pei Y, Chen Y, Sun Q, Cai JB, Zhou J, Fan J, Ke AW, Shi Y*, Shen Y*, Zhang P*, Shi G*, Yang G*. Loss of 5-hydroxymethylcytosine induces chemotherapy resistance in hepatocellular carcinoma via the 5-hmC/PCAF/AKT axis. Cell Death Dis. 2023 Feb 2;14(2):79.
(4) Lu J#, Zhang P#, Huang X#, Guo X#, Gao C, Zeng H, Zheng Y, Wang S, Cai J, Sun Q, Shi Y, Zhou J, Ke A*, Shi G*, Fan J*. Amplification of spatially isolated adenosine pathway by tumor-macrophage interaction induces anti-PD1 resistance in hepatocellular carcinoma. J Hematol Oncol. 2021 Nov 27;14(1):200.
(5) Guo X#, Lu J#, Zeng H#, Zhou R#, Sun Q#, Yang G, Pei Y, Meng X, Shen Y, Zhang P, Cai J, Huang P, Ke A, Shi Y, Zhou J, Fan J, Chen Y*, Yang L*, Shi G*, Huang X*. CTLA-4 Synergizes With PD1/PD-L1 in the Inhibitory Tumor Microenvironment of Intrahepatic Cholangiocarcinoma. Front Immunol. 2021 Aug 30;12:705378.
学术奖励：
国家奖学金（2021）
地址：上海市徐汇区医学院路138号 
邮编：200032 
电话/传真：021-54237056 
邮箱：itbr@fudan.edu.cn 
