Current Lab Members-INSTITUTE FOR TRANSLATIONAL BRAIN RESEARCH

Current Lab Members

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E-mail: xuruishen(AT)fudan

Research Direction: Mechanism of intracellular homeostasis

Brief Biography:

Education:

September 2016 – June 2022
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Ph.D. in Pharmacology (Science)
September 2012 – June 2016
Lanzhou University
B.Sc. in Life Sciences and Technology

Publications

(1) Shen X^#, Zhang J^#, Sun P, Zhong H, He R, Wang S, Guo X, Yang, H. Mechanistic insight into Manganese Transport by SLC30A10, Nature Communications, 2025, 16:8581

(2) Zhong H^#, Shen X^#,*, Yang H*. (2026). A Cell-Based Protocol to Assess Manganese Content and Relative Transport Activity of Manganese Transporters. Bio-protocol 16(9): e5680.

(3) Wu Y^#, Lin H^#, Li W^#, Wang X^#, Shen X^#, Lin X, Zhu L, Wang R, Yang T, Yi S, Ye R, Yang H*, Zhang Y*, Zhang J*, Fan M*. Structure and mechanism of the heterotetrameric ADP-glucose pyrophosphorylase essential for starch synthesis in plants. Science Advances, 2026, 12: aeb6384

(4) Zhang J^#, Shen X^#,*, Wu Y^#, Lu Q, Gordiyenko Y, Li L, Guo Z, Wang X, Zhong H, Li X*, Wang T*, Yang H*. Repeat-expanded C9orf72 mRNA engages the human ribosome to initiate non-AUG translation. LTS preprint, 2026

(5) Sun P^#, Wang X^#, Huang Y^#, Zhang J, Shen X, Dong A, Wang S, Guo X, Shi G, Ding J*, Chi Y*, Yang H*. Substrate Coupling and Inhibition of the human Na⁺-dependent Cl⁻/HCO₃⁻ exchanger NCBE. bioRxiv 2025 (Nat. Commun. 2026, in press)

(6) Shen X^#, He R^#, Zhong H, Sun P, Zhang J, Zhang Y, Yang H*. (2025). Oxa1L buffers mitochondrial vulnerability by coupling translation to membrane insertion. bioRxiv 2025.12.22.696118

(7) Shen X, Sun P, Zhang H, Yang H. Mitochondrial quality control in the brain: The physiological and pathological roles, Frontiers in Neuroscience, 2022, 16:1075141.

(8) Xia B^#, Shen X^#, He Y^#, Pan X^#, Liu FL^#, Wang Y, Yang F, Fang S, George F.G, Duan Z, Zuo X, Xie Z, Jiang X, Xu L, Chi H, Li SQ, Meng Q, Zhou H, Zhou Y, Cheng X, Xin X, Jin L, Zhang HL, Yu D, Li MH, Feng X, Chen J, Jiang H, Xiao G, Zheng YT, Zhang L, Shen J, Li J, Gao Z. SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, Cell Research, 2021, 31(8): 847-860.

(9) Xia B^#, Pan X^#, Luo RH^#, Shen X^#, Li S, Wang Y, Zuo X, Wu Y, Guo Y, Xiao G, Li Q, Long X, He X, Zheng HY, Lu Y, Pang W, Zheng YT, Li J, Zhang LK, Gao Z. Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2, Cell Discovery, 2023, 9(1).

(10) Xia B^#, Qie J^#, Shen X, Wang S, Gao Z. Enhanced channel activity by PI(4,5)P2 ignites MLKL-related pathogenic processes, Cell Discovery, 2022, 8(1).

(11) Wang Y^#, Fang S^#, George F.G, Cheng X, Zhang L, Shen X, Li S, Xu J, Shang W, Gao Z, Xia B. Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates, Acta pharmacologica Sinica, 2022, 43(4): 781-787.

Honors and Awards

Shanghai "Super Postdoctoral Fellow" (2023)
Outstanding Graduate of Shanghai (2022)
Second Prize for Oral Presentation, Graduate Academic Annual Conference, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (2022)
Outstanding Youth League Cadre, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (2019)
Merit Student (Excellent in Morality, Study, and Health), University of Chinese Academy of Sciences (2018–2019)
Outstanding Graduate of Lanzhou University (2016)