1. The origin of microglia under physiological and pathological conditions;
2. Neurodegenerative disorders;
3. Novel strategies for microglial replacement (transplantation);
4. The correlation of neuroimmunology and CNS aging.
Email:14211520017@fudan.edu.cn
Research Direction:microglia and neuroimmunology
Email:21718145@zju.edu.cn
Research Direction:microglia and neuroimmunology
Email:doris0313@163.com
Research Direction:Neuroimmunology
Email:21111520006@m.fudan.edu.cn
Research Direction:Neuroimmunology
Email:wjc0270@163.com
Research Direction:Microglia and Neuroinflammation
Email:liyuxin_3729@163.com
Research Direction:Neuroimmunology
Email:15110419302@163.com
Research Direction:Neuroimmunology
Email:16301030014@fudan.edu.cn
Research Direction:Neuroimmunology
Email:19301050196@fudan.edu.cn
Research Direction:Neuroimmunology
Email:caoyue29@126.com
Research Direction:Microglia and Neuroinflammation
Xu Z.#, Rao Y.#, Huang Y., Zhou T., Feng R., Xiong S., Yuan T.F., Qin S., Lu Y., Zhou X., Li X., Qin B., Mao Y. and Peng B.* (2020) Efficient strategies for microglia replacement in the central nervous system. Cell Reports 32, 108041.
Huang Y., Xu Z., Xiong S., Sun F., Qin G., Hu G., Wang J., Zhao L., Zhang C., Liang Y.X., Wu T, Lu Z, Humayun M.S., So K.F., Pan Y., Li N., Yuan T.F.*, Rao Y.* and Peng B.* (2018) Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion. Nature Neuroscience 21, 530-540.
Li X., Li Y., Jin Y., Zhang Y., Wu J., Xu Z., Huang Y., Cai L., Gao S., Liu T., Zeng F., Wang Y., Wang W., Yuan T.-F., Tian H., Shu Y., Guo F., Lu W., Mao Y., Mei X., Rao Y.* and Peng B.* (2023) Transcriptional and epigenetic decoding of the microglial aging process. Nature Aging 3, 1288-1311.
Rao Y.*, Du S., Yang B., Wang Y., Li Y., Li R., Zhou T., Du X., He Y., Wang Y., Zhou X., Yuan T.-F.,*, Mao Y.* and Peng B.* (2021) NeuroD1 induces microglial apoptosis and cannot induce microglia-to-neuron cross-lineage reprogramming, Neuron 109, 4094-4108.e4095.
He Y., Liu T., He Q., Ke W., Li X., Du J., Deng S., Shu Z., Wu J., Yang B., Wang Y., Mao Y., Rao Y., Shu Y.* and Peng B.* (2023) Microglia facilitate and stabilize the response to general anesthesia via modulating the neuronal network in a brain region-specific manner. eLife 12, RP92252.
Zhou T., Li Y., Li X., Zeng F., Rao Y., He Y., Wang Y., Liu M., Li D., Xu Z., Zhou X., Du S., Niu F., Peng J., Mei X., Ji S.-J., Shu Y., Lu W., Guo F., Wu T., Yuan T.-F., Mao Y. and Peng B.* (2022) Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice, Nature Communications 13, 6233. 10.1038/s41467-022-33932-3.
Huang Y., Xu Z., Xiong S., Qin G., Sun F., Yang J, Yuan T.F. Zhao L, Wang K, Liang Y.X., Fu L., Wu T, Lu Z, So K.F., Rao Y.* and Peng B.* (2018) Dual origins of retinal microglia in the model of microglia repopulation. Cell Discovery 4, 9.
Niu F., Han P., Zhang J., She Y., Yang L., Yu J., Zhuang M., Tang K., Shi Y., Yang B., Liu C., Peng B.* and Ji S.-J.* (2022) The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells. eLife 11, e75827.
Rao, Y. and Peng, B.* (2023). Allogenic microglia replacement: A novel therapeutic strategy for neurological disorders. Fundamental Research.
Zhang, L., Wang, Y., Liu, T., Mao, Y. and Peng, B.* (2023). Novel Microglia-based Therapeutic Approaches to Neurodegenerative Disorders. Neuroscience Bulletin 39, 491-502.
Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M. E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., Bennett, F., Bessis, A., Biber, K., Bilbo, S., Blurton-Jones, M., Boddeke, E., Brites, D., Brone, B., Brown, G. C., Butovsky, O., Carson, M. J., Castellano, B., Colonna, M., Cowley, S. A., Cunningham, C., Davalos, D., De Jager, P. L., de Strooper, B., Denes, A., Eggen, B. J. L., Eyo, U., Galea, E., Garel, S., Ginhoux, F., Glass, C. K., Gokce, O., Gomez-Nicola, D., Gonzalez, B., Gordon, S., Graeber, M. B., Greenhalgh, A. D., Gressens, P., Greter, M., Gutmann, D. H., Haass, C., Heneka, M. T., Heppner, F. L., Hong, S., Hume, D. A., Jung, S., Kettenmann, H., Kipnis, J., Koyama, R., Lemke, G., Lynch, M., Majewska, A., Malcangio, M., Malm, T., Mancuso, R., Masuda, T., Matteoli, M., McColl, B. W., Miron, V. E., Molofsky, A. V., Monje, M., Mracsko, E., Nadjar, A., Neher, J. J., Neniskyte, U., Neumann, H., Noda, M., Peng, B., Peri, F., Perry, V. H., Popovich, P. G., Pridans, C., Priller, J., Prinz, M., Ragozzino, D., Ransohoff, R. M., Salter, M. W., Schaefer, A., Schafer, D. P., Schwartz, M., Simons, M., Smith, C. J., Streit, W. J., Tay, T. L., Tsai, L. H., Verkhratsky, A., von Bernhardi, R., Wake, H., Wittamer, V., Wolf, S. A., Wu, L. J. and Wyss-Coray, T. (2022). Microglia states and nomenclature: A field at its crossroads. Neuron 110, 3458-3483. 10.1016/j.neuron.2022.10.020.
Xu, Z., Zhou, X., Peng, B.* and Rao, Y.* (2021). Microglia replacement by bone marrow transplantation (Mr BMT) in the central nervous system of adult mice. STAR Protocols 2, 100666.
Xu, Z., Rao, Y.* and Peng, B.* (2021). Protocol for microglia replacement by peripheral blood (Mr PB). STAR Protocols 2, 100613.
Xu, Z., Peng, B.* and Rao, Y.* (2021). Microglia replacement by microglia transplantation (Mr MT) in the adult mouse brain. STAR Protocols 2, 100665.
Rao, Y., Peng, B.* (2022) Failure of observing NeuroD1-induced microglia-to-neuron conversion in vitro is not attributed to the low NeuroD1 expression level. Molecular Brain 15 (1), 31
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Postcode: 200032
Telephone/Fax: 021-54237056
Email: peng@fudan.edu.cn