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Neural Mechanisms of Chronic Pain

Pain sensation is critical for animals to sense the changing environment for potential danger, and thus is important for the survival of animals. Chronic pain, however, has been reported to affect the lives of more than 15% of adults.What's more devastating is a lack of viable treatment. Our recent discovery of the functional role of the ipsilateral spino-parabrachial pathway in pain sensation provides a critical foundation for the study of the central mechanism of pain processing. The research interest of our lab is to understand the cellular and circuit mechanisms contributing to the sensory and affective components of chronic pain using a combination of viral tracing, optogenetic, pharmacogenetic and behavioral techniques. With a long term goal of identifying new targets for the treatment of chronic pain. Current projects include:

1. The function and plasticity of supraspinal circuits – involved in the development of chronic pain

2. The neural circuits/pathways that regulate pain-related negative emotions

3. How pain percept can be modulated based on respective physiological states

Pain sensation is critical for animals to sense the changing environment for potential danger, and thus is important for the survival of animals. Chronic pain, however, has been reported to affect the lives of more than 15% of adults.What's more devastating is a lack of viable treatment. Our recent discovery of the functional role of the ipsilateral spino-parabrachial pathway in pain sensation provides a critical foundation for the study of the central mechanism of pain processing. The research interest of our lab is to understand the cellular and circuit mechanisms contributing to the sensory and affective components of chronic pain using a combination of viral tracing, optogenetic, pharmacogenetic and behavioral techniques. With a long term goal of identifying new targets for the treatment of chronic pain. Current projects include:

1. The function and plasticity of supraspinal circuits – involved in the development of chronic pain

2. The neural circuits/pathways that regulate pain-related negative emotions

3. How pain percept can be modulated based on respective physiological states

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