We found a segregated distribution of Na+ channel subtypes Nav1.6 and Nav1.2 at the axon initial segment (AIS). Nav1.6 determines action potential initiation, while Nav1.2 subsequently promotes its backpropagation towards the somatodendritic compartments. Hu et al., 2009. Also see comments: Dulla and Huguenard, 2009.
Prev：The function of inhibitory microcircuit in the neocortex is regulated by neuronal membrane potential (Vm) levels.
Next：Asynchronous glutamate release regulates the function of inhibitory microcircuits.
Address:No.138, medical college road 
Postcode:200032 
Tel/Fax:021-54237056
Emial:itbr@fudan.edu.cn