邮箱：hao_zhang@fudan.edu.cn
研究方向：肿瘤发生相关通路噬神经性机制、脑疾病相关蛋白稳态的分子基础
经历简介:
工作经历
2022-至今，复旦大学脑科学转化研究院，青年副研究员
2020-2022，上海交通大学医学院附属瑞金医院，博士后
教育经历
2016-2020，上海交通大学，生命科学技术学院，理学博士
代表性论文
(1) Zhang H#, Cheng N#, Li Z#, Bai L#, Fang C, Li Y, Zhang W, Dong X, Jiang M, Liang Y, Zhang S, Mi J, Zhu J, Zhang Y, Chen SJ, Zhao Y, Weng XQ, Hu W*, Chen Z*, Huang J*, Meng G*. DN A crosslinking and recombination-activating genes 1/2 (RAG1/2) are required for oncogenic splicing in acute lymphoblastic leukemia. Cancer Communications, 2021; 41 (11):1116–1136.
(2) Shen X#, Sun P#, Zhang H* & Yang H*. Mitochondrial quality control in the brain: The physiological and pathological roles. Frontiers in Neuroscience, 2022; 16:1075141.
(3) Zhang H# and Meng G*. A typical bedside-to-bench investigation of leukemogenic driver MEF2D fusion reveals new targeted therapy in B-cell acute lymphoblastic leuke mia. Blood Science, 2022; 4(3):161-163.
(4) Zhang M#, Zhang H#, Li Z#, Bai L#, Wang Q, Li J, Jiang M, Xue Q, Cheng N, Zhang W, Mao D, Chen Z, Huang J, Meng G*, Chen Z*, Chen SJ *. Functional, structural and mol ecular characterizations of leukemogenic driver MEF2D-HNRNPUL1 fusion. Blood, 2022; 140(12):1390-1407.
(5) Tan S#, Zhang H#, Chai Y#, Song H, Tong Z, Wang Q, Qi J, Wong G, Zhu X, Liu WJ, Gao S, Wang Z, Shi Y, Yang F, George F. Gao* & Jinghua Yan*. An unexpected N-terminal loop in PD-1 dominates binding by nivolumab. Nature Communications, 2017; 8:14369.
(6) Dong X#, Zhang H#, Cheng N#, Li K, Meng G*. DUX4HD2-DNAERG structure reveals new insight into DUX4-Responsive-Element. Leukemia, 2019; 33(2):550-553.
(7) Chen D#, Tan S#, Zhang H#, Wang H#, He W, Shi R, Tong Z, Zhu J, Cheng H, Gao S, Chai Y, Qi J, Xiao M, Jinghua Yan*& George F. Gao*. The FG Loop of PD-1 Serves as a “Hotspot” for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy. iScience, 2019; 14:113-124.
(8) Cheng N#, Zhang H#*, Zhang S, Ma X*, Meng G*. Crystal structure of the GTP-binding protein-like domain of AGAP1. Acta Crystallographica Section F-structural Biology Communications, 2021; 77(Pt 4):105-112.
(9) Chen Z#, Wang Q#, Zhang H#, Ma X#, Wu W, Cheng N, Zhang J, Zhou A, Li Y, Meng G*. Purification, crystalli zation, and X-ray diffraction analysis of myocyte enhancer factor 2D and DNA complex. Protein Expression and Purification, 2021; 179:105788.
(10) Li Y, Ma X, Chen Z, Wu H, Wang P, Wu W, Cheng N, Zeng L, Zhang H, Cai X, Chen SJ, Chen Z, Meng G*. B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis. Nature Communications, 2019; 10(1):3789.
(11) Dong X, Zhang W, Wu H, Huang J, Zhang M, Wang P, Zhang H, Chen Z, Chen SJ *, Meng G*. Structural basis of DUX4-driven transactivation in B-ALL. Leukemia, 2018; 32(6):1466-1476.
学术奖励：
国家自然科学基金青年科学基金项目（2022年）
上海高水平地方高校建设人才引进项目（2022年）
华夏医学科技奖三等奖（2021年）
地址：上海市徐汇区医学院路138号 
邮编：200032 
电话/传真：021-54237056 
邮箱：itbr@fudan.edu.cn 
