离子通道和转运蛋白在神经元的电信号（动作电位）产生以及神经元之间的通讯（化学神经递质）中发挥着重要的作用。动作电位可以通过不同的刺激例如温度、压力、pH、氧气、光和其他信号分子调节离子通道活性而产生。动作电位引起神经递质释放到突触间隙中，结合并活化突触后膜表面受体，进一步引起突触后膜膜电位变化，实现神经信号的转导。课题组的研究兴趣在于理解神经电信号传导中离子通道和神经递质转运蛋白的分子机制和工作机理。利用结构生物学、电生理学和生物化学等手段揭示离子通道或神经递质转运蛋白底物结合、离子运输、门控机制以及其他小分子活性调节原理。
1. Li, B.#, Hoel, C. M.#, & Brohawn, S. G.* (2021). Structures of Tweety Homolog Proteins TTYH2 and TTYH3 reveal a Ca2+-dependent switch from intra- to inter-membrane dimerization. Nature Communications. https://doi.org/10.1038/s41467-021-27283-8
2. Rietmeijer, R. A.#, Sorum, B.#, Li, B., & Brohawn, S. G.* (2021). Physical basis for distinct basal and mechanically gated activity of the human K+ channel TRAAK. Neuron. https://doi.org/10.1016/j.neuron.2021.07.009
3. Li, B.#, Rietmeijer, R. A.#, & Brohawn, S. G.* (2020). Structural basis for pH gating of the two-pore domain K+ channel TASK2. Nature. https://doi.org/10.1038/s41586-020-2770-2
4. Hu, C. W.#, Worth, M.#, Fan, D.#, Li, B.#, Li, H.#, Lu, L., Zhong, X., Lin, Z., Wei, L., Ge, Y., Li, L., & Jiang, J.* (2017). Electrophilic probes for deciphering substrate recognition by o-glcnac transferase. Nature Chemical Biology. https://doi.org/10.1038/nchembio.2494
5. Li, B.#, Li, H.#, Hu, C. W., & Jiang, J.* (2017). Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase. Nature Communications. https://doi.org/10.1038/s41467-017-00865-1
6. Li, B., Li, H., Lu, L., & Jiang, J.* (2017). Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode. Nature Structural and Molecular Biology. https://doi.org/10.1038/nsmb.3390
7. Li, B.#, Wang, Q.#, Pan, X., De Castro, I. F., Sun, Y., Guo, Y., Tao, X., Risco, C., Sui, S. F., & Lou, Z.* (2013). Bunyamwera virus possesses a distinct nucleocapsid protein to facilitate genome encapsidation. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.1222552110
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