主要研究方向为以小鼠为模式生物研究：1. 不同尺度生存威胁触发的本能防御行为的神经环路机制与疾病发生；2. 自闭症、强迫症、惊恐、抑郁和焦虑等精神疾病相关行为的神经环路机制及潜在的改善方法。课题组主要运用光遗传学、化学遗传学、Ca成像和微型显微镜、在体电生理和脑片电生理、神经环路示踪、行为学分析、在体给药、RNA-Seq多种手段开展原创性的神经环路机制研究，以期揭示本能防御行为和精神疾病相关行为的发生和调控机制，为改善精神疾病症状提供新的潜在治疗方法。
Xie, Z. # *, Zhang, X. #, Zhao, M. #, Huo, L. #, Huang, M., Li, D., Zhang, S., Cheng, X., Gu, H., Zhang, C., Zhan, C., Wang, F. *, Shang, C. * & Cao, P.*. The gut-to-brain axis for toxin-induced defensive responses. Cell, 185, 4298-4316.e21, (2022).
Xie, Z. #, Gu, H. #, Huang, M. #, Cheng, X., Shang, C., Tao, T., Li, D., Xie, Y., Lu, W., Zhang, Z., Zhang, C., Tang, Z., Zhang, F. *& Cao, P.*. Mechanically evoked defensive attack is controlled by GABAergic neurons in the anterior hypothalamic nucleus. Nature Neuroscience, 25, 72-85, (2022).
Xie, Z. #, Li, D. #, Cheng, X. #, Pei, Q. #, Gu, H. #, Tao, T., Huang, M., Shang, C., Geng, D., Zhao, M., Liu, A., Zhang, C., Zhang, F. *, Ma, Y. * & Cao, P. *. A brain-to-spinal sensorimotor loop for repetitive self-grooming. Neuron, 110, 874-890.e877, (2022).
Xie, Z. #, Wang, M. #, Liu, Z. #, Shang, C. #, Zhang, C., Sun, L., Gu, H., Ran, G., Pei, Q., Ma, Q., Huang, M., Zhang, J., Lin, R., Zhou, Y., Zhang, J., Zhao, M., Luo, M., Wu, Q. *, Cao, P. * & Wang, X. *. Transcriptomic encoding of sensorimotor transformation in the midbrain. eLife 10, (2021).
Huang, M. #, Li, D. #, Cheng, X. #, Pei, Q. #, Xie, Z. #, Gu, H., Zhang, X., Chen, Z., Liu, A., Wang, Y., Sun, F., Li, Y., Zhang, J., He, M., Xie, Y., Zhang, F., Qi, X., Shang, C. * & Cao, P. *. The tectonigral pathway regulates appetitive locomotion in predatory hunting in mice. Nature Communications 12, 4409, (2021).
Shang, C. #, Liu, A. #, Li, D. #, Xie, Z. #, Chen, Z., Huang, M., Li, Y., Wang, Y., Shen, W. L. & Cao, P. * A subcortical excitatory circuit for sensory-triggered predatory hunting in mice. Nature Neuroscience 22, 909-920, (2019).
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地址：上海市徐汇区医学院路138号 
邮编：200032 
电话/传真：021-54237056 
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