Kan Yang#, Wei-Ke Li#, Yi-Xiao Geng#, Shu-Qian Zhang#, Shi-Hao Wu#, Yan-Bo Cheng#, Jun-Wen Wang, Zhan-Kui Xu, Wen-Xin Wang, Tan-Ying Zhang, Pei-Ye Wang, Yi-Ting Yuan, Juan Fan, Jun Wu, Ruo-Chuan Xu, Yue-Fang Zhang, Gong-Jia Tao, Zheng-Hui Li, Chen-Xi Lin, Tian-Shu Li, Xin-Yi Zhang, Jie-Li, Ru Zhang, Wen-Xiu Yang, Jia-Shuo Wen, Zun-Yuan Yang, Li Gong, Wen Zeng, Ai-Lian Du, Jin-Song LI, Fei Li*, Tian-Lin Cheng*, Zilong Qiu* In vivo base editing of Chd3 rescues behavioral abnormalities in mice, Nature, 2026, 651, 785–795 （Nature杂志News and Views专题评论https://www.nature.com/articles/d41586-026-00291-8；Nature biotechnology杂志Research Highlight研究亮点https://www.nature.com/articles/s41587-026-03070-y ）
Wei-Ke Li#, Shu-Qian Zhang#, Wan-Ling Peng, Yu-Han Shi, Bo Yuan, Yi-Ting Yuan, Zhen-Yu Xue, Jin-Cheng Wang, Wen-Jian Han, Zhi-Fang Chen, Shi-Fang Shan, Bi-Qing Xue, Jin-Long Chen, Cheng Zhang, Shu-Jia Zhu, Yi-Lin Tai, Min Xu, Tian-Lin Cheng*, Zi-Long Qiu*, Whole-brain in vivo base editing reverses behavioral changes in Mef2c-mutant mice, Nature Neuroscience, 2024, 27, 116–128
Cheng Zhang#, Ziliang Chen#, Jixin Cao#, Zui Zhang#, Wei-Ke Li#, Xinyi Zhang, Junying Chen, Jun Liu, Zhou Yuan, Feng Gao, Zehao Shi, Xing-Ming Zhao*, Jingqi Chen*, Changyou Zhan*, Tian-Lin Cheng*, RNA Inosine Sensor-Guided TadA Mutational Scanning for Toxicity Minimization of Adenine Base Editors, Molecular Therapy, 2026 Jan 7;34(1):380-396.
Jixin Cao#, Cheng Zhang#, Chun-Yi Zac Lo, Qihao Guo, Jing Ding, Xiaohui Luo, Zi-Chao Zhang, Feng Chen, the ZIB Consortium, Tian-Lin Cheng*, Jingqi Chen*, Xing-Ming Zhao* for the Alzheimer's Disease Neuroimaging Initiative, Integrating rare pathogenic variant prioritization with gene-based association analysis to identify novel genes and relevant multi-modal traits for Alzheimer's disease, Alzheimer's & Dementia, 2024, doi: 10.1002/alz.14444.
Zhang, S., Song, L., Yuan, B., Zhang, C., Cao, J., Chen, J., Qiu, J., Tai, Y., Chen, J., Qiu, Z., Zhao, X. M., & Cheng, T. L. (2023). TadA reprogramming to generate potent miniature base editors with high precision. Nature communications, 2023, 14:413
Zhang, S., Yuan, B., Cao, J., Song, L., Chen, J., Qiu, J., Qiu, Z., Zhao, X. M., Chen, J., & Cheng, T. L. (2023). TadA orthologs enable both cytosine and adenine editing of base editors. Nature communications, 2023, 14:414
Bo Yuan#, Shuqian Zhang#, Liting Song#, Jinlong Chen, Jixin Cao, Jiayi Qiu, Zilong Qiu, Jingqi Chen*, Xing-Ming Zhao*, Tian-Lin Cheng*, Engineering of cytosine base editors with DNA damage minimization and editing scope diversification, Nucleic Acids Research, 2023, gkad855
Li Shuo, Bo Yuan, Jixin Cao, Jingqi Chen, Jinlong Chen, Jiayi Qiu, Xing-Ming Zhao, Xiaolin Wang*, Zilong Qiu*, Tian-Lin Cheng* (2020). Docking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination, Nature Communications, 11:5827.
Tian-Lin Cheng*, Shuo Li, Bo Yuan, Xiaolin Wang, Wenhao Zhou, Zilong Qiu* (2019). Expanding C-T base editing toolkit with diversified cytidine deaminases, Nature Communications, 10:3612
Yuan Cai#,Tianlin Cheng#,Yichuan Yao#, Xiao Li, Yuqian Ma, Lingyun Li, Huan Zhao, Jin Bao, Mei Zhang*, Zilong Qiu*, Tian Xue*(2019). In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway, Science Advances, eaav3335
Tian-Lin Cheng*, Zilong Qiu*(2019). Long non-coding RNA tagging and expression manipulation via CRISPR/Cas9-mediated targeted insertion, Protein Cell, 9: 820
Tian-Lin Cheng, Zhizhi Wang, Qiuming Liao, Ying Zhu, Wen-Hao Zhou, Wenqing Xu, Zilong Qiu*(2014). MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex, Developmental Cell, 28:547-560
Tian-Lin Cheng*; Zilong Qiu*; MeCP2: multifaceted roles in gene regulation and neural development, Neuroscience Bulletin, 2014, 30(4): 601-609
Zhen Liu#; Xiao Li#; Jun-Tao Zhang; Yi-Jun Cai; Tian-Lin Cheng; Cheng Cheng; Yan Wang; Chen-Chen Zhang; Yan-Hong Nie; Zhi-Fang Chen; Wen-Jie Bian; Ling Zhang; Jianqiu Xiao; Bin Lu; Yue-Fang Zhang; Xiao-Di Zhang; Xiao Sang; Jia-Jia Wu; Xiu Xu; Zhi-Qi Xiong; Feng Zhang; Xiang Yu; Neng Gong; Wen-Hao Zhou; Qiang Sun*; Zilong Qiu*; Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2, Nature, 2016, 530(7588): 98-102
地址：上海市徐汇区医学院路138号 
邮编：200032 
电话/传真：021-54237056 
邮箱：itbr@fudan.edu.cn 地址：上海市徐汇区医学院路138号，邮编：200032，电话：54237056，复旦大学脑科学转化研究院 版权所有
