Dr. Wang has long specialized in neurobiology research, systematically investigating how ion channels and ion homeostasis modulate neuronal survival and development, as well as their pathological implications for neural diseases. He has addressed critical questions about the calcium sources underlying neurotrophic factor-regulated neuronal survival, neural development, and plasticity. His work has also revealed the pivotal role of TRPC6 in ischemic brain injury and Aβ amyloid formation. Additionally, he has led a team in researching brain-inspired computing inspired by biological vision, enhancing the capability to detect and track small, slow-moving targets in complex backgrounds.
Email:pumei@fudan.edu.cn
Research Direction:Mechanisms and treatment of neurodegenerative diseases.
Email:licy1224@163.com
Research Direction:Neural circuit mechanisms of PTSD.
Email:yuanyufan@fudan.edu.cn
Research Direction:Neurobiology.
Email:23111220035@m.fudan.edu.cn
Research Direction:Mechanisms and treatment of neurodegenerative diseases.
Email:xu.yaling@foxmail.com
Research Direction:Role and mechanisms of neural circuits in depression.
Email:22211520012@m.fudan.edu.cn
Research Direction:Neural circuits and mechanisms of Parkinson’s disease–related movement disorders
Email:23111520001@m.fudan.edu.cn
Research Direction:Neural circuit mechanisms of PTSD.
Email:2633793125@qq.com
Research Direction:Regulatory mechanisms of motor behavior in anxiety.
Email:z17826157269@163.com
Research Direction:Mechanisms and treatment of neurodegenerative diseases.
Email:22211520026@m.fudan.edu.cn
Research Direction:Neural circuits and mechanisms of Parkinson’s disease–related movement disorders
Xiaoyue Gao, Qiyuan Zhuang, Yun Li, Guochao Li, Zheng Huang, Shenzhi Chen, Shaoxing Sun, Hui Yang#, Lan Jiang#, Ying Mao#. Single‐Cell Chromatin Accessibility Analysis Reveals Subgroup‐Specific TF‐NTR Regulatory Circuits in Medulloblastoma . Advanced Science, 2024:e2309554
Qiyuan Zhuang, Ying Liu, Hanze Wang, Ziyang Lin, Li Sun, Yue Liu, Yingying Lyu, Liang Chen, Hui Yang#, Ying Mao#, LILRB3 suppresses immunity in glioma and is associatedwith poor prognosis. Clinical and Translational Medicine, 2023 Oct;13(10):e1396
Qi Fan, Hanze Wang, Tianyi Gu, Huihui Liu, Peng Deng, Bo Li, Hui Yang#, Ying Mao#, Zhicheng Shao#.Modeling the precise interaction of glioblastoma with human brain region-specific organoids. iScience, 2024 Feb 5;27(3):109111
Qi Liu, Fangming Zhu, Xinnan Liu,., Hui Yang#, Bin Li# and Xuemei Tong#, Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics. Nature Metabolism, 2022, 4:559–574. (#corresponding author).
News & Views: TKT deficiency puts Tregs to rest (Nature Metabolism)
Xiang Gui*, Hui Yang*, Tuo Li, Xiaojun Tan, Peiqing Shi, Minghao Li, Fenghe Du & Zhijian J. Chen. Autophagy induction via STING trafficking is a primordial function of the cGAS pathway. Nature, 2019, 567: 262–266. (*Contribute equally) , ESI高被引论文(1%), Highlighted by: Nature, Nature Reviews Molecular Cell Biology. Selected by: Faculty of 1000.
Hui Yang, Hanze Wang, Junyao Ren, Qi Chen, and Zhijian J. Chen. cGAS is Essential for Cellular Senescence. PNAS, 2017, 114(23):E4612-E4620. ESI高被引论文(1%),Highlighted by: Nature, Immunity, Nature Cell Biology.
Wei Xu*, Hui Yang*, Ying Liu*, Ying Yang, Ping Wang, Se-Hee Kim, Shinsuke Ito, Chen Yang, Pu Wang, Meng-Tao Xiao, Li-xia Liu, Wen-qing Jiang, Jing Liu, Jin-ye Zhang, Bin Wang, Stephen Frye, Yi Zhang, Yan-hui Xu, Qun-ying Lei, Kun-Liang Guan, Shi-min Zhao, and Yue Xiong. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011,19:17 (* Contribute equally, Cover story) , ESI高被引论文(1%), Selected by: Faculty of 1000
Hao Lin, Chaxian Liu, Ankang Hu, Duanwu Zhang, # Hui Yang#, Ying Mao#. Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives. Journal of Hematology & Oncology, 2024 May 8;17(1):31
Qiyuan Zhuang, Hui Yang#, Ying Mao#. The oncogenesis of glial cells in diffuse gliomas and clinical opportunities. Neuroscience Bulletin, 2023 Mar;39(3):393-408
Yingying Lyu, Hui Yang#, Liang Chen#,. Metabolic regulation on the immune environment of glioma through gut microbiota. Seminars in Cancer Biology, 2021 May 7; S1044-579. (#corresponding author)
Yang, Hui. Beutler, Beutler. & Zhang, Duanwu. Emerging roles of spliceosome in cancer and immunity. Protein Cell .2021.
Ankang Hu, Li Sun, Hao Lin, Yuheng Liao, Hui Yang#, Ying Mao#. Harnessing innate immune pathways for therapeutic advancement in cancer. Signal Transduction and Targeted Therapy, 2024 Mar 25;9(1):68
Hui Yang*, Lisha Zhou*, Yuzheng Zhao, Yi Yang, Yue Xiong, Dan Ye, and Kun-Liang Guan. SIRT3-dependent GOT2 acetylation status affects the malate–aspartate NADH shuttle activity and pancreatic tumor growth. EMBO Journal, 2015, 34: 1110. (*Contribute equally)
Hui Yang, Huaipeng Lin, Haiyan Xu, Lei Zhang, Lu Cheng, Bo Wen, Jianyong Shou, Kun-Liang Guan, Yue Xiong, and Dan Ye. TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites. Cell Research. 2014,24:1017
Hui Yang#, Yingying Lyu, Fajian Hou#. SARS-CoV-2 infection and the antiviral innate immune response. Journal of Molecular Cell Biology, DOI:10.1093/jmcb/mjaa071. (#corresponding author).
Address: Floor 3, Building B, Medical Research Building, 131 Dong'an Road
Postcode: 200032
Email: wangyizheng@fudan.edu.cn