主要研究方向为研究脑内免疫细胞在中枢神经系统疾病中的作用，针对感染、肿瘤、自身免疫病、脑外伤等引起大脑脂代谢紊乱与过度炎症反应、神经损伤、神经核团功能障碍、肿瘤微环境等影响神经系统疾病的病理机制，开展诊断、预防和干预的临床转化研究。课题组主要运用光遗传学、量子点标记、双（多）光子荧光显微镜、代谢组/转录组/蛋白质组等高通量筛选技术、质谱流式、微流控芯片等多种手段开展原创性抗感染、佐剂、神经损伤修复和药物靶向递送的技术开发工作。
Yang D#, Tian T, Li X, Zhang B, Qi L, Zhang F, Han M, Wang S, Xiao J, Gou Y, Zhang R, Liu Q, Su S, Liu J, Huang X, Gao Q, Hui L, Tang H, Wang H*, Wei B*. ZNT1 and Zn2+ control TLR4 and PD-L1 endocytosis in macrophage to improve chemotherapy efficacy against liver tumor. Hepatology. 2023 Oct 9. doi: 10.1097/HEP.0000000000000629. Online ahead of print.
Zhang F#, Zhang B#, Ding H, Li X, Wang X, Zhang X, Liu Q, Feng Q, Han M, Chen L, Qi L, Yang D, Li X, Zhu X, Zhao Q, Qiu J, Zhu Z, Tang H, Shen N*, Wang H*, Wei B*. The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus. Adv Sci (Weinh). 2023 Jul 19:e2207108.
Li X#, Qi L#, Yang D, Hao S, Zhang F, Zhu X, Sun Y, Chen C, Ye J, Yang J, Zhao L, Altmann DM, Cao S, Wang H*, Wei B*. Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system. Nature Neuroscience. 2022 May;25(5):577-587. Highlighted by Nature Reviews of Neurology July 16th, 2022.
Zhang F#, Qi LL#, Feng Q, Zhang B, Li X, Liu C, Li W, Liu Q, Yang D, Yin Y, Peng C, Wu H, Tang Z, Zhou X, Xiang Z, Zhang Z, Wang H*, Wei B*. 2021 Jul 13. HIPK2 phosphorylates HDAC3 for NF-κB acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis. PNAS;118(28):e2021798118.
Xiao J#, Li W#, Zheng X, Qi L, Wang H, Zhang C, Wan X, Zheng Y, Zhong R, Zhou X, Lu Y, Li Z, Qiu Y, Liu C, Zhang F, Zhang Y, Xu X, Yang Z, Chen H, Zhai Q, Wei B*, Wang H*. 2020 Jan 14. Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection. Immunity. 52(1):109-122.e6.
Lu Y#, Qiu Y#, Chen P, Chang H, Guo L, Zhang F, Ma L, Zhang C, Xiao J, Zhong R, Han L, Xu X, Zhang Y, Li D, Zhong G, Boyton R, Huang Y, He Y, Hu R*, Wei B*, Wang H*. 2019 Dec. The ER-localised Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection. Nature Microbiology;4(12):2331-2346.
地址: 上海市徐汇区东安路131号医学科研楼二楼
邮编: 200032
电话/传真: 021-54237056
邮箱: weibin@fudan.edu.cn
地址：上海市徐汇区医学院路138号 
邮编：200032 
电话/传真：021-54237056 
邮箱：itbr@fudan.edu.cn 地址：上海市徐汇区医学院路138号，邮编：200032，电话：54237056，复旦大学脑科学转化研究院 版权所有
