Picture-INSTITUTE FOR TRANSLATIONAL BRAIN RESEARCH

Picture-INSTITUTE FOR TRANSLATIONAL BRAIN RESEARCH

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The ER-localised Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection.
HIPK2 phosphorylates HDAC3 for NF-κB acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis.
The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus.
ZNT1 and Zn2+ control TLR4 and PD-L1 endocytosis in macrophage to improve chemotherapy efficacy against liver tumor.
VEGFR-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection.
Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system.