1.小胶质细胞更替;
2.小胶质细胞在生理和病理情况下的起源;
3.以小胶质细胞为调控靶点对神经退行性病变进行干预治疗的策略研究;
4.开发小胶质细胞替换/移植策略;
5.神经免疫与疾病衰老的关系;
6.小胶质细胞与稳态维持;
7.小胶质细胞重编程与干细胞。
Rao Y.*, Du S., Yang B., Wang Y., Li Y., Li R., Zhou T., Du X., He Y., Wang Y., Zhou X., Yuan T.-F.,*, Mao Y.,* and Peng B.* (2021) NeuroD1 induces microglial apoptosis and cannot induce microglia-to-neuron cross-lineage reprogramming, Neuron 109, 4094-4108.e4095.
Xu Z.#, Rao Y.#, Huang Y., Zhou T., Feng R., Xiong S., Yuan T.F., Qin S., Lu Y., Zhou X., Li X., Qin B., Mao Y., and Peng B.* (2020) Efficient strategies for microglia replacement in the central nervous system. Cell Reports 32, 108041.
Huang Y., Xu Z., Xiong S., Sun F., Qin G., Hu G., Wang J., Zhao L., Zhang C., Liang Y.X., Wu T, Lu Z, Humayun M.S., So K.F., Pan Y., Li N., Yuan T.F.*, Rao Y.*, and Peng B.* (2018) Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion. Nature Neuroscience 21, 530-540.
Zhou T., Li Y., Li X., Zeng F., Rao Y., He Y., Wang Y., Liu M., Li D., Xu Z., Zhou X., Du S., Niu F., Peng J., Mei X., Ji S.-J., Shu Y., Lu W., Guo F., Wu T., Yuan T.-F., Mao Y. and Peng B.* (2022) Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice, Nature Communications 13, 6233. 10.1038/s41467-022-33932-3.
Huang Y., Xu Z., Xiong S., Qin G., Sun F., Yang J, Yuan T.F. Zhao L, Wang K, Liang Y.X., Fu L., Wu T, Lu Z, So K.F., Rao Y.* and Peng B.* (2018) Dual origins of retinal microglia in the model of microglia repopulation. Cell Discovery 4, 9.
Niu F., Han P., Zhang J., She Y., Yang L., Yu J., Zhuang M., Tang K., Shi Y., Yang B., Liu C., Peng B.* and Ji S.-J.* (2022) The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells. eLife 11, e75827.
Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M. E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., Bennett, F., Bessis, A., Biber, K., Bilbo, S., Blurton-Jones, M., Boddeke, E., Brites, D., Brone, B., Brown, G. C., Butovsky, O., Carson, M. J., Castellano, B., Colonna, M., Cowley, S. A., Cunningham, C., Davalos, D., De Jager, P. L., de Strooper, B., Denes, A., Eggen, B. J. L., Eyo, U., Galea, E., Garel, S., Ginhoux, F., Glass, C. K., Gokce, O., Gomez-Nicola, D., Gonzalez, B., Gordon, S., Graeber, M. B., Greenhalgh, A. D., Gressens, P., Greter, M., Gutmann, D. H., Haass, C., Heneka, M. T., Heppner, F. L., Hong, S., Hume, D. A., Jung, S., Kettenmann, H., Kipnis, J., Koyama, R., Lemke, G., Lynch, M., Majewska, A., Malcangio, M., Malm, T., Mancuso, R., Masuda, T., Matteoli, M., McColl, B. W., Miron, V. E., Molofsky, A. V., Monje, M., Mracsko, E., Nadjar, A., Neher, J. J., Neniskyte, U., Neumann, H., Noda, M., Peng, B., Peri, F., Perry, V. H., Popovich, P. G., Pridans, C., Priller, J., Prinz, M., Ragozzino, D., Ransohoff, R. M., Salter, M. W., Schaefer, A., Schafer, D. P., Schwartz, M., Simons, M., Smith, C. J., Streit, W. J., Tay, T. L., Tsai, L. H., Verkhratsky, A., von Bernhardi, R., Wake, H., Wittamer, V., Wolf, S. A., Wu, L. J. and Wyss-Coray, T. (2022). Microglia states and nomenclature: A field at its crossroads. Neuron 110, 3458-3483. 10.1016/j.neuron.2022.10.020.
Xu, Z., Zhou, X., Peng, B.*, and Rao, Y.* (2021). Microglia replacement by bone marrow transplantation (Mr BMT) in the central nervous system of adult mice. STAR Protocols 2, 100666.
Xu, Z., Rao, Y.*, and Peng, B.* (2021). Protocol for microglia replacement by peripheral blood (Mr PB). STAR Protocols 2, 100613.
Xu, Z., Peng, B.*, and Rao, Y.* (2021). Microglia replacement by microglia transplantation (Mr MT) in the adult mouse brain. STAR Protocols 2, 100665.
Rao, Y., Peng, B.* (2022) Failure of observing NeuroD1-induced microglia-to-neuron conversion in vitro is not attributed to the low NeuroD1 expression level. Molecular Brain 15 (1), 31
地址:上海市东安路131号医学科研2号楼B座二楼
邮编:200032
电话/传真:021-54237056
邮箱:peng@fudan.edu.cn