WeiGuang Li-INSTITUTE FOR TRANSLATIONAL BRAIN RESEARCH

WeiGuang Li

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WeiGuang Li Principal Investigator

Memory Principles and Applications

Dr. Wei-Guang Li is currently a Principal Investigator and professor at the Institute for Translational Brain Research and an adjunct professor at Huashan Hospital, Fudan University. He received his bachelor degree in Basic Medicine at Sichuan University in 2006. He received his Ph.D. degree in Neurobiology at Institute of Neuroscience, Chinese Academy of Sciences in 2011. He then went to Shanghai Jiao Tong University School of Medicine for postdoctoral training and was appointed as a faculty member there in 2014 (from assistant investigator, associate investigator to investigator). In September 2021, he joined Fudan University and established a laboratory entitled “Memory Principles and Applications”. The primary goal of his laboratory is aiming at elucidating the biological basis of memory engram in the context of dynamic processes including memory extinction and relapse, forgetting and remembering, and to explore the role of memory conditioning in the regulation of metabolic, immune and other pathophysiological processes through cross-disciplinary approaches. His previous work has been published as first or corresponding (including co-corresponding) author in Neuron, Molecular Psychiatry, National Science Review, Nature Communications, Science Advances, Cell Reports and other academic journals.

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Focusing on the general direction of "Memory Principles and Applications", relying on the advantages of the institute in intersectional, integrational, and translational brain research（ITBR）, we are committed to promoting the innovative application of modern molecular biology, Advanced Microscopy, cell biology and other related technologies in memory research with an emphasis on the memory types such as emotional memory, feeding memory, and motor memory. We have been long engaged in analyzing the basic features of memory engrams and their neurobiological basis from multiple dimensions, portraying the physiological nature of normal life activities such as emotion, nutritional metabolism, motor behaviors and their impairments, with the goal of reconstruction and synthesis. Meanwhile, we are also going to expand the application of memory principles in brain-body interaction regulation to understand the symptom evolution and functional rehabilitation in chronic diseases. We hope to develop new methods and modalities of peripheral and central stimulation that are capable of evoking persistent changes in brain activity equivalent to "memory", and then to address the evolutionary process and molecular driving forces of characteristic cell ensembles with a markedly pro-rehabilitation effect in the brain, and ultimately to establish new strategies of disease intervention based on memory principles for clinical translation and application.